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Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives

A series of tricyclic penciclovir (PCV) and hydroxybutylguanine (HBG) derivatives have been prepared with enhanced lipophilicity following an efficient synthetic route. All the novel tricyclic derivatives were evaluated for inhibitory activity against herpes simplex virus 1 and 2 (HSV-1, HSV-2) and...

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Detalles Bibliográficos
Autores principales:	Mohammed, Anber F., Andrei, Graciela, Hayallah, Alaa M., Abdel-Moty, Samia G., Snoeck, Robert, Simons, Claire
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Ltd. 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126098/ https://www.ncbi.nlm.nih.gov/pubmed/30738653 http://dx.doi.org/10.1016/j.bmc.2019.02.005

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