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Gut microbes as future therapeutics in treating inflammatory and infectious diseases: Lessons from recent findings()
The human gut microbiota has been the interest of extensive research in recent years and our knowledge on using the potential capacity of these microbes are growing rapidly. Microorganisms colonized throughout the gastrointestinal tract of human are coevolved through symbiotic relationship and can i...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126101/ https://www.ncbi.nlm.nih.gov/pubmed/30196243 http://dx.doi.org/10.1016/j.jnutbio.2018.07.010 |
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author | Mukherjee, Suprabhat Joardar, Nikhilesh Sengupta, Subhasree Sinha Babu, Santi P. |
author_facet | Mukherjee, Suprabhat Joardar, Nikhilesh Sengupta, Subhasree Sinha Babu, Santi P. |
author_sort | Mukherjee, Suprabhat |
collection | PubMed |
description | The human gut microbiota has been the interest of extensive research in recent years and our knowledge on using the potential capacity of these microbes are growing rapidly. Microorganisms colonized throughout the gastrointestinal tract of human are coevolved through symbiotic relationship and can influence physiology, metabolism, nutrition and immune functions of an individual. The gut microbes are directly involved in conferring protection against pathogen colonization by inducing direct killing, competing with nutrients and enhancing the response of the gut-associated immune repertoire. Damage in the microbiome (dysbiosis) is linked with several life-threatening outcomes viz. inflammatory bowel disease, cancer, obesity, allergy, and auto-immune disorders. Therefore, the manipulation of human gut microbiota came out as a potential choice for therapeutic intervention of the several human diseases. Herein, we review significant studies emphasizing the influence of the gut microbiota on the regulation of host responses in combating infectious and inflammatory diseases alongside describing the promises of gut microbes as future therapeutics. |
format | Online Article Text |
id | pubmed-7126101 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71261012020-04-08 Gut microbes as future therapeutics in treating inflammatory and infectious diseases: Lessons from recent findings() Mukherjee, Suprabhat Joardar, Nikhilesh Sengupta, Subhasree Sinha Babu, Santi P. J Nutr Biochem Article The human gut microbiota has been the interest of extensive research in recent years and our knowledge on using the potential capacity of these microbes are growing rapidly. Microorganisms colonized throughout the gastrointestinal tract of human are coevolved through symbiotic relationship and can influence physiology, metabolism, nutrition and immune functions of an individual. The gut microbes are directly involved in conferring protection against pathogen colonization by inducing direct killing, competing with nutrients and enhancing the response of the gut-associated immune repertoire. Damage in the microbiome (dysbiosis) is linked with several life-threatening outcomes viz. inflammatory bowel disease, cancer, obesity, allergy, and auto-immune disorders. Therefore, the manipulation of human gut microbiota came out as a potential choice for therapeutic intervention of the several human diseases. Herein, we review significant studies emphasizing the influence of the gut microbiota on the regulation of host responses in combating infectious and inflammatory diseases alongside describing the promises of gut microbes as future therapeutics. Elsevier Inc. 2018-11 2018-08-16 /pmc/articles/PMC7126101/ /pubmed/30196243 http://dx.doi.org/10.1016/j.jnutbio.2018.07.010 Text en © 2018 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Mukherjee, Suprabhat Joardar, Nikhilesh Sengupta, Subhasree Sinha Babu, Santi P. Gut microbes as future therapeutics in treating inflammatory and infectious diseases: Lessons from recent findings() |
title | Gut microbes as future therapeutics in treating inflammatory and infectious diseases: Lessons from recent findings() |
title_full | Gut microbes as future therapeutics in treating inflammatory and infectious diseases: Lessons from recent findings() |
title_fullStr | Gut microbes as future therapeutics in treating inflammatory and infectious diseases: Lessons from recent findings() |
title_full_unstemmed | Gut microbes as future therapeutics in treating inflammatory and infectious diseases: Lessons from recent findings() |
title_short | Gut microbes as future therapeutics in treating inflammatory and infectious diseases: Lessons from recent findings() |
title_sort | gut microbes as future therapeutics in treating inflammatory and infectious diseases: lessons from recent findings() |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126101/ https://www.ncbi.nlm.nih.gov/pubmed/30196243 http://dx.doi.org/10.1016/j.jnutbio.2018.07.010 |
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