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A dynamic model for infectious diseases: The role of vaccination and treatment

Understanding dynamics of an infectious disease helps in designing appropriate strategies for containing its spread in a population. Recent mathematical models are aimed at studying dynamics of some specific types of infectious diseases. In this paper we propose a new model for infectious diseases s...

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Detalles Bibliográficos
Autores principales: Raja Sekhara Rao, P., Naresh Kumar, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126230/
https://www.ncbi.nlm.nih.gov/pubmed/32288363
http://dx.doi.org/10.1016/j.chaos.2015.02.004
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author Raja Sekhara Rao, P.
Naresh Kumar, M.
author_facet Raja Sekhara Rao, P.
Naresh Kumar, M.
author_sort Raja Sekhara Rao, P.
collection PubMed
description Understanding dynamics of an infectious disease helps in designing appropriate strategies for containing its spread in a population. Recent mathematical models are aimed at studying dynamics of some specific types of infectious diseases. In this paper we propose a new model for infectious diseases spread having susceptible, infected, and recovered populations and study its dynamics in presence of incubation delays and relapse of the disease. The influence of treatment and vaccination efforts on the spread of infection in presence of time delays are studied. Sufficient conditions for local stability of the equilibria and change of stability are derived in various cases. The problem of global stability is studied for an important special case of the model. Simulations carried out in this study brought out the importance of treatment rate in controlling the disease spread. It is observed that incubation delays have influence on the system even under enhanced vaccination. The present study has clearly brought out the fact that treatment rate even in presence of time delays would contain the disease as compared to popular belief that eradication can only be done through vaccination.
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spelling pubmed-71262302020-04-08 A dynamic model for infectious diseases: The role of vaccination and treatment Raja Sekhara Rao, P. Naresh Kumar, M. Chaos Solitons Fractals Article Understanding dynamics of an infectious disease helps in designing appropriate strategies for containing its spread in a population. Recent mathematical models are aimed at studying dynamics of some specific types of infectious diseases. In this paper we propose a new model for infectious diseases spread having susceptible, infected, and recovered populations and study its dynamics in presence of incubation delays and relapse of the disease. The influence of treatment and vaccination efforts on the spread of infection in presence of time delays are studied. Sufficient conditions for local stability of the equilibria and change of stability are derived in various cases. The problem of global stability is studied for an important special case of the model. Simulations carried out in this study brought out the importance of treatment rate in controlling the disease spread. It is observed that incubation delays have influence on the system even under enhanced vaccination. The present study has clearly brought out the fact that treatment rate even in presence of time delays would contain the disease as compared to popular belief that eradication can only be done through vaccination. Elsevier Ltd. 2015-06 2015-02-24 /pmc/articles/PMC7126230/ /pubmed/32288363 http://dx.doi.org/10.1016/j.chaos.2015.02.004 Text en Copyright © 2015 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Raja Sekhara Rao, P.
Naresh Kumar, M.
A dynamic model for infectious diseases: The role of vaccination and treatment
title A dynamic model for infectious diseases: The role of vaccination and treatment
title_full A dynamic model for infectious diseases: The role of vaccination and treatment
title_fullStr A dynamic model for infectious diseases: The role of vaccination and treatment
title_full_unstemmed A dynamic model for infectious diseases: The role of vaccination and treatment
title_short A dynamic model for infectious diseases: The role of vaccination and treatment
title_sort dynamic model for infectious diseases: the role of vaccination and treatment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126230/
https://www.ncbi.nlm.nih.gov/pubmed/32288363
http://dx.doi.org/10.1016/j.chaos.2015.02.004
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