New quaternary ammonium camphor derivatives and their antiviral activity, genotoxic effects and cytotoxicity

The synthesis and biological evaluation of a novel series of dimeric camphor derivatives are described. The resulting compounds were studied for their antiviral activity, cyto- and genotoxicity. Compounds 3a and 3d in which the quaternary nitrogen atoms are separated by the C5H10 and С9H18 aliphatic...

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Autores principales: Sokolova, Anastasiya S., Yarovaya, Оlga I., Shernyukov, Аndrey V., Pokrovsky, Мichail A., Pokrovsky, Аndrey G., Lavrinenko, Valentina A., Zarubaev, Vladimir V., Tretiak, Tatiana S., Anfimov, Pavel M., Kiselev, Oleg I., Beklemishev, Anatoly B., Salakhutdinov, Nariman F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126328/
https://www.ncbi.nlm.nih.gov/pubmed/23993669
http://dx.doi.org/10.1016/j.bmc.2013.08.014
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author Sokolova, Anastasiya S.
Yarovaya, Оlga I.
Shernyukov, Аndrey V.
Pokrovsky, Мichail A.
Pokrovsky, Аndrey G.
Lavrinenko, Valentina A.
Zarubaev, Vladimir V.
Tretiak, Tatiana S.
Anfimov, Pavel M.
Kiselev, Oleg I.
Beklemishev, Anatoly B.
Salakhutdinov, Nariman F.
author_facet Sokolova, Anastasiya S.
Yarovaya, Оlga I.
Shernyukov, Аndrey V.
Pokrovsky, Мichail A.
Pokrovsky, Аndrey G.
Lavrinenko, Valentina A.
Zarubaev, Vladimir V.
Tretiak, Tatiana S.
Anfimov, Pavel M.
Kiselev, Oleg I.
Beklemishev, Anatoly B.
Salakhutdinov, Nariman F.
author_sort Sokolova, Anastasiya S.
collection PubMed
description The synthesis and biological evaluation of a novel series of dimeric camphor derivatives are described. The resulting compounds were studied for their antiviral activity, cyto- and genotoxicity. Compounds 3a and 3d in which the quaternary nitrogen atoms are separated by the C5H10 and С9H18 aliphatic chain, exhibited the highest efficiency as an agent inhibiting the reproduction of the influenza virus A(H1N1)pdm09. The cytotoxicity data of compounds 3 and 4 revealed their moderate activity against malignant cell lines; compound 3f had the highest activity for the CEM-13 cells. These results show close agreement with the data of independent studies on toxicity of these compounds, in particular that the toxicity of compounds strongly depends on spacer length.
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spelling pubmed-71263282020-04-08 New quaternary ammonium camphor derivatives and their antiviral activity, genotoxic effects and cytotoxicity Sokolova, Anastasiya S. Yarovaya, Оlga I. Shernyukov, Аndrey V. Pokrovsky, Мichail A. Pokrovsky, Аndrey G. Lavrinenko, Valentina A. Zarubaev, Vladimir V. Tretiak, Tatiana S. Anfimov, Pavel M. Kiselev, Oleg I. Beklemishev, Anatoly B. Salakhutdinov, Nariman F. Bioorg Med Chem Article The synthesis and biological evaluation of a novel series of dimeric camphor derivatives are described. The resulting compounds were studied for their antiviral activity, cyto- and genotoxicity. Compounds 3a and 3d in which the quaternary nitrogen atoms are separated by the C5H10 and С9H18 aliphatic chain, exhibited the highest efficiency as an agent inhibiting the reproduction of the influenza virus A(H1N1)pdm09. The cytotoxicity data of compounds 3 and 4 revealed their moderate activity against malignant cell lines; compound 3f had the highest activity for the CEM-13 cells. These results show close agreement with the data of independent studies on toxicity of these compounds, in particular that the toxicity of compounds strongly depends on spacer length. Elsevier Ltd. 2013-11-01 2013-08-12 /pmc/articles/PMC7126328/ /pubmed/23993669 http://dx.doi.org/10.1016/j.bmc.2013.08.014 Text en Copyright © 2013 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Sokolova, Anastasiya S.
Yarovaya, Оlga I.
Shernyukov, Аndrey V.
Pokrovsky, Мichail A.
Pokrovsky, Аndrey G.
Lavrinenko, Valentina A.
Zarubaev, Vladimir V.
Tretiak, Tatiana S.
Anfimov, Pavel M.
Kiselev, Oleg I.
Beklemishev, Anatoly B.
Salakhutdinov, Nariman F.
New quaternary ammonium camphor derivatives and their antiviral activity, genotoxic effects and cytotoxicity
title New quaternary ammonium camphor derivatives and their antiviral activity, genotoxic effects and cytotoxicity
title_full New quaternary ammonium camphor derivatives and their antiviral activity, genotoxic effects and cytotoxicity
title_fullStr New quaternary ammonium camphor derivatives and their antiviral activity, genotoxic effects and cytotoxicity
title_full_unstemmed New quaternary ammonium camphor derivatives and their antiviral activity, genotoxic effects and cytotoxicity
title_short New quaternary ammonium camphor derivatives and their antiviral activity, genotoxic effects and cytotoxicity
title_sort new quaternary ammonium camphor derivatives and their antiviral activity, genotoxic effects and cytotoxicity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126328/
https://www.ncbi.nlm.nih.gov/pubmed/23993669
http://dx.doi.org/10.1016/j.bmc.2013.08.014
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