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Segmentation of DNA using simple recurrent neural network
We report the discovery of strong correlations between protein coding regions and the prediction errors when using the simple recurrent network to segment genome sequences. We are going to use SARS genome to demonstrate how we conduct training and derive corresponding results. The distribution of pr...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126336/ https://www.ncbi.nlm.nih.gov/pubmed/32288315 http://dx.doi.org/10.1016/j.knosys.2011.09.001 |
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author | Cheng, Wei-Chen Huang, Jau-Chi Liou, Cheng-Yuan |
author_facet | Cheng, Wei-Chen Huang, Jau-Chi Liou, Cheng-Yuan |
author_sort | Cheng, Wei-Chen |
collection | PubMed |
description | We report the discovery of strong correlations between protein coding regions and the prediction errors when using the simple recurrent network to segment genome sequences. We are going to use SARS genome to demonstrate how we conduct training and derive corresponding results. The distribution of prediction error indicates how the underlying hidden regularity of the genome sequences and the results are consistent with the finding of biologists: predicated protein coding features of SARS genome. This implies that the simple recurrent network is capable of providing new features for further biological studies when applied on genome studies. The HA gene of influenza A subtype H1N1 is also analyzed in a similar way. |
format | Online Article Text |
id | pubmed-7126336 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71263362020-04-08 Segmentation of DNA using simple recurrent neural network Cheng, Wei-Chen Huang, Jau-Chi Liou, Cheng-Yuan Knowl Based Syst Article We report the discovery of strong correlations between protein coding regions and the prediction errors when using the simple recurrent network to segment genome sequences. We are going to use SARS genome to demonstrate how we conduct training and derive corresponding results. The distribution of prediction error indicates how the underlying hidden regularity of the genome sequences and the results are consistent with the finding of biologists: predicated protein coding features of SARS genome. This implies that the simple recurrent network is capable of providing new features for further biological studies when applied on genome studies. The HA gene of influenza A subtype H1N1 is also analyzed in a similar way. Elsevier B.V. 2012-02 2011-09-17 /pmc/articles/PMC7126336/ /pubmed/32288315 http://dx.doi.org/10.1016/j.knosys.2011.09.001 Text en Copyright © 2011 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Cheng, Wei-Chen Huang, Jau-Chi Liou, Cheng-Yuan Segmentation of DNA using simple recurrent neural network |
title | Segmentation of DNA using simple recurrent neural network |
title_full | Segmentation of DNA using simple recurrent neural network |
title_fullStr | Segmentation of DNA using simple recurrent neural network |
title_full_unstemmed | Segmentation of DNA using simple recurrent neural network |
title_short | Segmentation of DNA using simple recurrent neural network |
title_sort | segmentation of dna using simple recurrent neural network |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126336/ https://www.ncbi.nlm.nih.gov/pubmed/32288315 http://dx.doi.org/10.1016/j.knosys.2011.09.001 |
work_keys_str_mv | AT chengweichen segmentationofdnausingsimplerecurrentneuralnetwork AT huangjauchi segmentationofdnausingsimplerecurrentneuralnetwork AT liouchengyuan segmentationofdnausingsimplerecurrentneuralnetwork |