New muramyl dipeptide (MDP) mimics without the carbohydrate moiety as potential adjuvant candidates for a therapeutic hepatitis B vaccine (HBV)

A series of new muramyl dipeptide (MDP) mimics were designed and synthesized via a solid-phase synthetic route. Their adjuvant activities were evaluated ex vivo for investigation of the synergism of the S(28–39) peptide, which is an MHC class I binding epitope of recombinant hepatitis B surface anti...

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Detalles Bibliográficos
Autores principales: Zhao, Nan, Ma, Yao, Zhang, Shengmei, Fang, Xin, Liang, Zhenglun, Liu, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126364/
https://www.ncbi.nlm.nih.gov/pubmed/21683593
http://dx.doi.org/10.1016/j.bmcl.2011.05.056
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author Zhao, Nan
Ma, Yao
Zhang, Shengmei
Fang, Xin
Liang, Zhenglun
Liu, Gang
author_facet Zhao, Nan
Ma, Yao
Zhang, Shengmei
Fang, Xin
Liang, Zhenglun
Liu, Gang
author_sort Zhao, Nan
collection PubMed
description A series of new muramyl dipeptide (MDP) mimics were designed and synthesized via a solid-phase synthetic route. Their adjuvant activities were evaluated ex vivo for investigation of the synergism of the S(28–39) peptide, which is an MHC class I binding epitope of recombinant hepatitis B surface antigen (HBsAg) for both humans and mice. Several compounds without the carbohydrate moiety exerted better adjuvanticity than the MDP-C that has been reported by our laboratory previously. A primary screening test revealed that compounds 6, 14 and 16 exhibited stronger adjuvanticity compared with other MDP mimics.
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spelling pubmed-71263642020-04-08 New muramyl dipeptide (MDP) mimics without the carbohydrate moiety as potential adjuvant candidates for a therapeutic hepatitis B vaccine (HBV) Zhao, Nan Ma, Yao Zhang, Shengmei Fang, Xin Liang, Zhenglun Liu, Gang Bioorg Med Chem Lett Article A series of new muramyl dipeptide (MDP) mimics were designed and synthesized via a solid-phase synthetic route. Their adjuvant activities were evaluated ex vivo for investigation of the synergism of the S(28–39) peptide, which is an MHC class I binding epitope of recombinant hepatitis B surface antigen (HBsAg) for both humans and mice. Several compounds without the carbohydrate moiety exerted better adjuvanticity than the MDP-C that has been reported by our laboratory previously. A primary screening test revealed that compounds 6, 14 and 16 exhibited stronger adjuvanticity compared with other MDP mimics. Elsevier Ltd. 2011-07-15 2011-05-25 /pmc/articles/PMC7126364/ /pubmed/21683593 http://dx.doi.org/10.1016/j.bmcl.2011.05.056 Text en Copyright © 2011 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Zhao, Nan
Ma, Yao
Zhang, Shengmei
Fang, Xin
Liang, Zhenglun
Liu, Gang
New muramyl dipeptide (MDP) mimics without the carbohydrate moiety as potential adjuvant candidates for a therapeutic hepatitis B vaccine (HBV)
title New muramyl dipeptide (MDP) mimics without the carbohydrate moiety as potential adjuvant candidates for a therapeutic hepatitis B vaccine (HBV)
title_full New muramyl dipeptide (MDP) mimics without the carbohydrate moiety as potential adjuvant candidates for a therapeutic hepatitis B vaccine (HBV)
title_fullStr New muramyl dipeptide (MDP) mimics without the carbohydrate moiety as potential adjuvant candidates for a therapeutic hepatitis B vaccine (HBV)
title_full_unstemmed New muramyl dipeptide (MDP) mimics without the carbohydrate moiety as potential adjuvant candidates for a therapeutic hepatitis B vaccine (HBV)
title_short New muramyl dipeptide (MDP) mimics without the carbohydrate moiety as potential adjuvant candidates for a therapeutic hepatitis B vaccine (HBV)
title_sort new muramyl dipeptide (mdp) mimics without the carbohydrate moiety as potential adjuvant candidates for a therapeutic hepatitis b vaccine (hbv)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126364/
https://www.ncbi.nlm.nih.gov/pubmed/21683593
http://dx.doi.org/10.1016/j.bmcl.2011.05.056
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