Optimized synthesis of aminooxy-peptides as glycoprobe precursors for surface-based sugar–protein interaction studies

An improved procedure for solid phase coupling of Boc-aminooxyacetic acid to peptides is described. By avoiding base-containing activation mixtures which cause over-acylation, it practically suppresses this unwanted side reaction and leads to near quantitative yields of Aoa-peptides, useful as glyco...

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Detalles Bibliográficos
Autores principales: Jiménez-Castells, Carmen, de la Torre, Beatriz G., Gutiérrez Gallego, Ricardo, Andreu, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126385/
https://www.ncbi.nlm.nih.gov/pubmed/17629701
http://dx.doi.org/10.1016/j.bmcl.2007.06.090
Descripción
Sumario:An improved procedure for solid phase coupling of Boc-aminooxyacetic acid to peptides is described. By avoiding base-containing activation mixtures which cause over-acylation, it practically suppresses this unwanted side reaction and leads to near quantitative yields of Aoa-peptides, useful as glycoprobe precursors in glycomic studies.

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