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Stimulation and analysis of the immune response in calves from vaccinated pregnant cows
The effect of vaccinating pregnant cows with an inactivated vaccine against Mannheimia haemolytica, BRSV and PI3V infections on selected immune responses in their offspring was examined. Blood samples were collected weekly for 12 weeks from six newborn calves from each of vaccinated (experimental) a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Published by Elsevier Ltd.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126404/ https://www.ncbi.nlm.nih.gov/pubmed/24815344 http://dx.doi.org/10.1016/j.rvsc.2014.04.005 |
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author | Dudek, Katarzyna Bednarek, Dariusz Ayling, Roger D. Szacawa, Ewelina |
author_facet | Dudek, Katarzyna Bednarek, Dariusz Ayling, Roger D. Szacawa, Ewelina |
author_sort | Dudek, Katarzyna |
collection | PubMed |
description | The effect of vaccinating pregnant cows with an inactivated vaccine against Mannheimia haemolytica, BRSV and PI3V infections on selected immune responses in their offspring was examined. Blood samples were collected weekly for 12 weeks from six newborn calves from each of vaccinated (experimental) and unvaccinated (control) dams. Specific antibodies to M. haemolytica, BRSV and PI3V and mean values of IgA, IgG concentrations were significantly higher in the experimental calves compared with the controls. However, specific antibody titres to adenovirus type 3, BHV1 and BVDV in the experimental calves had constant levels while the control group levels changed. The IgM, Hp and SAA concentrations generally increased until week 8 in the experimental group, but the control group titres became higher after week 9. This study demonstrates that specific immunisation of cows pre-partum significantly stimulated parameters associated with immunity and it also controlled the acute phase response intensity in their offspring. Therefore the vaccination of dams may provide additional antibody protection against infection to their offspring. |
format | Online Article Text |
id | pubmed-7126404 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Published by Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71264042020-04-08 Stimulation and analysis of the immune response in calves from vaccinated pregnant cows Dudek, Katarzyna Bednarek, Dariusz Ayling, Roger D. Szacawa, Ewelina Res Vet Sci Article The effect of vaccinating pregnant cows with an inactivated vaccine against Mannheimia haemolytica, BRSV and PI3V infections on selected immune responses in their offspring was examined. Blood samples were collected weekly for 12 weeks from six newborn calves from each of vaccinated (experimental) and unvaccinated (control) dams. Specific antibodies to M. haemolytica, BRSV and PI3V and mean values of IgA, IgG concentrations were significantly higher in the experimental calves compared with the controls. However, specific antibody titres to adenovirus type 3, BHV1 and BVDV in the experimental calves had constant levels while the control group levels changed. The IgM, Hp and SAA concentrations generally increased until week 8 in the experimental group, but the control group titres became higher after week 9. This study demonstrates that specific immunisation of cows pre-partum significantly stimulated parameters associated with immunity and it also controlled the acute phase response intensity in their offspring. Therefore the vaccination of dams may provide additional antibody protection against infection to their offspring. Published by Elsevier Ltd. 2014-08 2014-04-23 /pmc/articles/PMC7126404/ /pubmed/24815344 http://dx.doi.org/10.1016/j.rvsc.2014.04.005 Text en Crown copyright © 2014 Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Dudek, Katarzyna Bednarek, Dariusz Ayling, Roger D. Szacawa, Ewelina Stimulation and analysis of the immune response in calves from vaccinated pregnant cows |
title | Stimulation and analysis of the immune response in calves from vaccinated pregnant cows |
title_full | Stimulation and analysis of the immune response in calves from vaccinated pregnant cows |
title_fullStr | Stimulation and analysis of the immune response in calves from vaccinated pregnant cows |
title_full_unstemmed | Stimulation and analysis of the immune response in calves from vaccinated pregnant cows |
title_short | Stimulation and analysis of the immune response in calves from vaccinated pregnant cows |
title_sort | stimulation and analysis of the immune response in calves from vaccinated pregnant cows |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126404/ https://www.ncbi.nlm.nih.gov/pubmed/24815344 http://dx.doi.org/10.1016/j.rvsc.2014.04.005 |
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