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A DNA vaccine producing LcrV antigen in oligomers is effective in protecting mice from lethal mucosal challenge of plague
There is an urgent need to develop effective vaccines against pneumonic plague, a highly lethal and contagious disease caused by the Gram-negative bacterium Yersinia pestis. Here we demonstrate that a novel DNA vaccine expressing a modified V antigen (LcrV) of Y. pestis, with a human tissue plasmino...
Autores principales: | Wang, Shixia, Heilman, Destin, Liu, Fangjun, Giehl, Theodore, Joshi, Swati, Huang, Xiaoyun, Chou, Te-hui, Goguen, Jon, Lu, Shan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Ltd.
2004
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126436/ https://www.ncbi.nlm.nih.gov/pubmed/15308359 http://dx.doi.org/10.1016/j.vaccine.2004.02.036 |
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