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Substrate specificity and phosphorylation of antiviral and anticancer nucleoside analogues by human deoxyribonucleoside kinases and ribonucleoside kinases

Structural analogues of nucleosides, nucleoside analogues (NA), are used in the treatment of cancer and viral infections. Antiviral NAs inhibit replication of the viral genome, whereas anticancer NAs inhibit cellular DNA replication and repair. NAs are inactive prodrugs that are dependent on intrace...

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Detalles Bibliográficos
Autores principales:	Van Rompay, An R, Johansson, Magnus, Karlsson, Anna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Inc. 2003
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126524/ https://www.ncbi.nlm.nih.gov/pubmed/14609716 http://dx.doi.org/10.1016/j.pharmthera.2003.07.001

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