Evaluation of a non-prime site substituent and warheads combined with a decahydroisoquinolin scaffold as a SARS 3CL protease inhibitor

A non-prime site substituent and warheads combined with a decahydroisoquinolin scaffold was evaluated as a novel inhibitor for severe acute respiratory syndrome (SARS) chymotrypsin-like protease (3CL(pro)). The decahydroisoquinolin scaffold has been demonstrated to be an effective hydrophobic center...

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Detalles Bibliográficos
Autores principales: Ohnishi, Kouji, Hattori, Yasunao, Kobayashi, Kazuya, Akaji, Kenichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126642/
https://www.ncbi.nlm.nih.gov/pubmed/30558861
http://dx.doi.org/10.1016/j.bmc.2018.12.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126642/
https://www.ncbi.nlm.nih.gov/pubmed/30558861
http://dx.doi.org/10.1016/j.bmc.2018.12.019

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