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Neutrophil activation and arteritis induced by C. albicans water-soluble mannoprotein-β-glucan complex (CAWS)
We have established a mouse model which shows the symptoms of coronary arteritis after consecutive injections of CAWS, which is released from Candida albicans. In this study, we examined neutrophil activation in the initial period after CAWS injection intraperitoneally. During 10 min to 16 h after t...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Published by Elsevier Inc.
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126757/ https://www.ncbi.nlm.nih.gov/pubmed/17208225 http://dx.doi.org/10.1016/j.yexmp.2006.05.006 |
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author | Ishida-Okawara, Akiko Nagi-Miura, Noriko Oharaseki, Toshiaki Takahashi, Kei Okumura, Akinori Tachikawa, Hitoshi Kashiwamura, Shin-ichiro Okamura, Haruki Ohno, Naohito Okada, Hidechika Ward, Peter A. Suzuki, Kazuo |
author_facet | Ishida-Okawara, Akiko Nagi-Miura, Noriko Oharaseki, Toshiaki Takahashi, Kei Okumura, Akinori Tachikawa, Hitoshi Kashiwamura, Shin-ichiro Okamura, Haruki Ohno, Naohito Okada, Hidechika Ward, Peter A. Suzuki, Kazuo |
author_sort | Ishida-Okawara, Akiko |
collection | PubMed |
description | We have established a mouse model which shows the symptoms of coronary arteritis after consecutive injections of CAWS, which is released from Candida albicans. In this study, we examined neutrophil activation in the initial period after CAWS injection intraperitoneally. During 10 min to 16 h after the injection, blood profiles and neutrophil functions were determined. At the same time, levels of inflammatory cytokines and chemokines in plasma were measured. Furthermore, level of ICAM-1 as a marker of lesion in arterial endothelial cells was measured. Counts of the peripheral leukocytes increased immediately after CAWS injection, especially involving neutrophil. In vitro sensitivity of neutrophils to stimuli was enhanced. Moreover, proinflammatory cytokines (IL-1β, IL-12 and IL-6) increased in plasma initially followed by an increase in IL-10, G-CSF, MIP-2 and soluble ICAM-1. Locally, ICAM-1 message in arterial walls was significantly increased 16 h after CAWS injection. A decrease in C3 levels was observed in plasma, suggesting complement activation and consumption. In summary, neutrophil activation occurred after CAWS injection, followed by complement activation, and production of proinflammatory cytokines chemokines and G-CSF which may be involved in development of coronary arteritis. |
format | Online Article Text |
id | pubmed-7126757 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Published by Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71267572020-04-06 Neutrophil activation and arteritis induced by C. albicans water-soluble mannoprotein-β-glucan complex (CAWS) Ishida-Okawara, Akiko Nagi-Miura, Noriko Oharaseki, Toshiaki Takahashi, Kei Okumura, Akinori Tachikawa, Hitoshi Kashiwamura, Shin-ichiro Okamura, Haruki Ohno, Naohito Okada, Hidechika Ward, Peter A. Suzuki, Kazuo Exp Mol Pathol Article We have established a mouse model which shows the symptoms of coronary arteritis after consecutive injections of CAWS, which is released from Candida albicans. In this study, we examined neutrophil activation in the initial period after CAWS injection intraperitoneally. During 10 min to 16 h after the injection, blood profiles and neutrophil functions were determined. At the same time, levels of inflammatory cytokines and chemokines in plasma were measured. Furthermore, level of ICAM-1 as a marker of lesion in arterial endothelial cells was measured. Counts of the peripheral leukocytes increased immediately after CAWS injection, especially involving neutrophil. In vitro sensitivity of neutrophils to stimuli was enhanced. Moreover, proinflammatory cytokines (IL-1β, IL-12 and IL-6) increased in plasma initially followed by an increase in IL-10, G-CSF, MIP-2 and soluble ICAM-1. Locally, ICAM-1 message in arterial walls was significantly increased 16 h after CAWS injection. A decrease in C3 levels was observed in plasma, suggesting complement activation and consumption. In summary, neutrophil activation occurred after CAWS injection, followed by complement activation, and production of proinflammatory cytokines chemokines and G-CSF which may be involved in development of coronary arteritis. Published by Elsevier Inc. 2007-04 2007-01-05 /pmc/articles/PMC7126757/ /pubmed/17208225 http://dx.doi.org/10.1016/j.yexmp.2006.05.006 Text en Copyright © 2006 Published by Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Ishida-Okawara, Akiko Nagi-Miura, Noriko Oharaseki, Toshiaki Takahashi, Kei Okumura, Akinori Tachikawa, Hitoshi Kashiwamura, Shin-ichiro Okamura, Haruki Ohno, Naohito Okada, Hidechika Ward, Peter A. Suzuki, Kazuo Neutrophil activation and arteritis induced by C. albicans water-soluble mannoprotein-β-glucan complex (CAWS) |
title | Neutrophil activation and arteritis induced by C. albicans water-soluble mannoprotein-β-glucan complex (CAWS) |
title_full | Neutrophil activation and arteritis induced by C. albicans water-soluble mannoprotein-β-glucan complex (CAWS) |
title_fullStr | Neutrophil activation and arteritis induced by C. albicans water-soluble mannoprotein-β-glucan complex (CAWS) |
title_full_unstemmed | Neutrophil activation and arteritis induced by C. albicans water-soluble mannoprotein-β-glucan complex (CAWS) |
title_short | Neutrophil activation and arteritis induced by C. albicans water-soluble mannoprotein-β-glucan complex (CAWS) |
title_sort | neutrophil activation and arteritis induced by c. albicans water-soluble mannoprotein-β-glucan complex (caws) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126757/ https://www.ncbi.nlm.nih.gov/pubmed/17208225 http://dx.doi.org/10.1016/j.yexmp.2006.05.006 |
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