Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4)

Chemokine-like factor 1 (CKLF1) exhibits chemotactic effects on leukocytes. Its amino acid sequence shares similarity with those of TARC/CCL17 and MDC/CCL22, the cognate ligands for CCR4. The chemotactic effects of CKLF1 for CCR4-transfected cells could be desensitized by TARC/CCL17 and markedly inh...

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Autores principales: Wang, Ying, Zhang, Yingmei, Yang, Xue, Han, Wenling, Liu, Yanan, Xu, Qianmei, Zhao, Rui, Di, Chunhui, Song, Quansheng, Ma, Dalong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126766/
https://www.ncbi.nlm.nih.gov/pubmed/16137713
http://dx.doi.org/10.1016/j.lfs.2005.05.070
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author Wang, Ying
Zhang, Yingmei
Yang, Xue
Han, Wenling
Liu, Yanan
Xu, Qianmei
Zhao, Rui
Di, Chunhui
Song, Quansheng
Ma, Dalong
author_facet Wang, Ying
Zhang, Yingmei
Yang, Xue
Han, Wenling
Liu, Yanan
Xu, Qianmei
Zhao, Rui
Di, Chunhui
Song, Quansheng
Ma, Dalong
author_sort Wang, Ying
collection PubMed
description Chemokine-like factor 1 (CKLF1) exhibits chemotactic effects on leukocytes. Its amino acid sequence shares similarity with those of TARC/CCL17 and MDC/CCL22, the cognate ligands for CCR4. The chemotactic effects of CKLF1 for CCR4-transfected cells could be desensitized by TARC/CCL17 and markedly inhibited by PTX. CKLF1 induced a calcium flux in CCR4-transfected cells and fully desensitized a subsequent response to TARC/CCL17, and TARC/CCL17 could partly desensitize the response to CKLF1. CKLF1 caused significant receptor internalization in pCCR4-EGFP transfected cells. Taken together, CKLF1 is a novel functional ligand for CCR4.
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spelling pubmed-71267662020-04-06 Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4) Wang, Ying Zhang, Yingmei Yang, Xue Han, Wenling Liu, Yanan Xu, Qianmei Zhao, Rui Di, Chunhui Song, Quansheng Ma, Dalong Life Sci Article Chemokine-like factor 1 (CKLF1) exhibits chemotactic effects on leukocytes. Its amino acid sequence shares similarity with those of TARC/CCL17 and MDC/CCL22, the cognate ligands for CCR4. The chemotactic effects of CKLF1 for CCR4-transfected cells could be desensitized by TARC/CCL17 and markedly inhibited by PTX. CKLF1 induced a calcium flux in CCR4-transfected cells and fully desensitized a subsequent response to TARC/CCL17, and TARC/CCL17 could partly desensitize the response to CKLF1. CKLF1 caused significant receptor internalization in pCCR4-EGFP transfected cells. Taken together, CKLF1 is a novel functional ligand for CCR4. Elsevier Inc. 2006-01-02 2005-08-30 /pmc/articles/PMC7126766/ /pubmed/16137713 http://dx.doi.org/10.1016/j.lfs.2005.05.070 Text en Copyright © 2005 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Wang, Ying
Zhang, Yingmei
Yang, Xue
Han, Wenling
Liu, Yanan
Xu, Qianmei
Zhao, Rui
Di, Chunhui
Song, Quansheng
Ma, Dalong
Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4)
title Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4)
title_full Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4)
title_fullStr Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4)
title_full_unstemmed Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4)
title_short Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4)
title_sort chemokine-like factor 1 is a functional ligand for cc chemokine receptor 4 (ccr4)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126766/
https://www.ncbi.nlm.nih.gov/pubmed/16137713
http://dx.doi.org/10.1016/j.lfs.2005.05.070
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