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Foot-and-mouth disease virus induces lysosomal degradation of host protein kinase PKR by 3C proteinase to facilitate virus replication

The interferon-induced double-strand RNA activated protein kinase (PKR) plays important roles in host defense against viral infection. Here we demonstrate the significant antiviral role of PKR against foot-and-mouth disease virus (FMDV) and report that FMDV infection inhibits PKR expression and acti...

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Detalles Bibliográficos
Autores principales:	Li, Chuntian, Zhu, Zixiang, Du, Xiaoli, Cao, Weijun, Yang, Fan, Zhang, Xiangle, Feng, Huanhuan, Li, Dan, Zhang, Keshan, Liu, Xiangtao, Zheng, Haixue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Inc. 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126777/ https://www.ncbi.nlm.nih.gov/pubmed/28662438 http://dx.doi.org/10.1016/j.virol.2017.06.023

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