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Molecular insight into the therapeutic potential of phytoconstituents targeting protein conformation and their expression

BACKGROUND: Native protein conformation is essential for the functional activity of the proteins and enzymes. Defects in conformation or alterations in expression of the proteins have been reported in various diseases. PURPOSE: The aim of this study is to review the molecular insight into the therap...

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Autor principal: Tiwari, Vishvanath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier GmbH. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126799/
https://www.ncbi.nlm.nih.gov/pubmed/30599902
http://dx.doi.org/10.1016/j.phymed.2018.09.214
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author Tiwari, Vishvanath
author_facet Tiwari, Vishvanath
author_sort Tiwari, Vishvanath
collection PubMed
description BACKGROUND: Native protein conformation is essential for the functional activity of the proteins and enzymes. Defects in conformation or alterations in expression of the proteins have been reported in various diseases. PURPOSE: The aim of this study is to review the molecular insight into the therapeutic potential of phytoconstituents targeting protein conformations or expressions. METHODS: Published literatures were searched in PubMed, Scopus, Web of Science; Article published till Dec 2017 were extracted. The literature was assessed from the Central University of Rajasthan, India. Present study evaluate article based on the role of active plant constituents on the conformation and expression of the different proteins. RESULTS: Plant components play their role either at the molecular level or cellular level and exhibit antibacterial, antiviral, anti-neurodegenerative and other activities. Plant active compounds isolated from different plants may either stabilize or destabilize the conformation of proteins or alter expression level of the protein involved in these diseases, therefore, can play a significant role in preventing diseases caused by the alteration in these proteins. CONCLUSION: In the present article, we have reviewed the molecular mechanism of plant active compounds, their target proteins, methods of extraction and identification, and their biological significances. Therefore, a proper understanding of the effect of these herbal molecules on the concerned proteins may help to develop new herbal-based therapeutics for various diseases.
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spelling pubmed-71267992020-04-08 Molecular insight into the therapeutic potential of phytoconstituents targeting protein conformation and their expression Tiwari, Vishvanath Phytomedicine Article BACKGROUND: Native protein conformation is essential for the functional activity of the proteins and enzymes. Defects in conformation or alterations in expression of the proteins have been reported in various diseases. PURPOSE: The aim of this study is to review the molecular insight into the therapeutic potential of phytoconstituents targeting protein conformations or expressions. METHODS: Published literatures were searched in PubMed, Scopus, Web of Science; Article published till Dec 2017 were extracted. The literature was assessed from the Central University of Rajasthan, India. Present study evaluate article based on the role of active plant constituents on the conformation and expression of the different proteins. RESULTS: Plant components play their role either at the molecular level or cellular level and exhibit antibacterial, antiviral, anti-neurodegenerative and other activities. Plant active compounds isolated from different plants may either stabilize or destabilize the conformation of proteins or alter expression level of the protein involved in these diseases, therefore, can play a significant role in preventing diseases caused by the alteration in these proteins. CONCLUSION: In the present article, we have reviewed the molecular mechanism of plant active compounds, their target proteins, methods of extraction and identification, and their biological significances. Therefore, a proper understanding of the effect of these herbal molecules on the concerned proteins may help to develop new herbal-based therapeutics for various diseases. Elsevier GmbH. 2019-01 2018-09-26 /pmc/articles/PMC7126799/ /pubmed/30599902 http://dx.doi.org/10.1016/j.phymed.2018.09.214 Text en © 2018 Elsevier GmbH. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Tiwari, Vishvanath
Molecular insight into the therapeutic potential of phytoconstituents targeting protein conformation and their expression
title Molecular insight into the therapeutic potential of phytoconstituents targeting protein conformation and their expression
title_full Molecular insight into the therapeutic potential of phytoconstituents targeting protein conformation and their expression
title_fullStr Molecular insight into the therapeutic potential of phytoconstituents targeting protein conformation and their expression
title_full_unstemmed Molecular insight into the therapeutic potential of phytoconstituents targeting protein conformation and their expression
title_short Molecular insight into the therapeutic potential of phytoconstituents targeting protein conformation and their expression
title_sort molecular insight into the therapeutic potential of phytoconstituents targeting protein conformation and their expression
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126799/
https://www.ncbi.nlm.nih.gov/pubmed/30599902
http://dx.doi.org/10.1016/j.phymed.2018.09.214
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