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The mannose-binding lectin: a prototypic pattern recognition molecule

The innate immune system is comprised of a sophisticated network of recognition and effector molecules that act together to protect the host in the first minutes or hours of exposure to an infectious challenge. The mannose-binding lectin (MBL) is an evolutionary conserved circulating host defense pr...

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Autores principales: Takahashi, Kazue, Ip, WK Eddie, Michelow, Ian C, Ezekowitz, R Alan B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126801/
https://www.ncbi.nlm.nih.gov/pubmed/16368230
http://dx.doi.org/10.1016/j.coi.2005.11.014
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author Takahashi, Kazue
Ip, WK Eddie
Michelow, Ian C
Ezekowitz, R Alan B
author_facet Takahashi, Kazue
Ip, WK Eddie
Michelow, Ian C
Ezekowitz, R Alan B
author_sort Takahashi, Kazue
collection PubMed
description The innate immune system is comprised of a sophisticated network of recognition and effector molecules that act together to protect the host in the first minutes or hours of exposure to an infectious challenge. The mannose-binding lectin (MBL) is an evolutionary conserved circulating host defense protein that acts as a broad-spectrum recognition molecule against a wide variety of infectious agents. Target binding triggers the MBL pathway of complement activation. MBL can be considered conceptually as an ‘ante-antibody’ because it has a role in mammals during the lag period that is required to develop an antibody response against infectious agents. Additionally, there are MBL-like homologues in animals that lack adaptive immunity that activate a primitive complement system, and under these circumstances these MBL-like molecules play an analogous role to antibodies in higher animals. These molecules might be considered to be functional antecedents of antibodies. Recent work also indicates that MBL recognizes altered self-antigens, and as such MBL has a role that extends beyond a traditional role in first line host defense as it appears to play a role as a modulator of inflammation.
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spelling pubmed-71268012020-04-08 The mannose-binding lectin: a prototypic pattern recognition molecule Takahashi, Kazue Ip, WK Eddie Michelow, Ian C Ezekowitz, R Alan B Curr Opin Immunol Article The innate immune system is comprised of a sophisticated network of recognition and effector molecules that act together to protect the host in the first minutes or hours of exposure to an infectious challenge. The mannose-binding lectin (MBL) is an evolutionary conserved circulating host defense protein that acts as a broad-spectrum recognition molecule against a wide variety of infectious agents. Target binding triggers the MBL pathway of complement activation. MBL can be considered conceptually as an ‘ante-antibody’ because it has a role in mammals during the lag period that is required to develop an antibody response against infectious agents. Additionally, there are MBL-like homologues in animals that lack adaptive immunity that activate a primitive complement system, and under these circumstances these MBL-like molecules play an analogous role to antibodies in higher animals. These molecules might be considered to be functional antecedents of antibodies. Recent work also indicates that MBL recognizes altered self-antigens, and as such MBL has a role that extends beyond a traditional role in first line host defense as it appears to play a role as a modulator of inflammation. Elsevier Ltd. 2006-02 2005-12-20 /pmc/articles/PMC7126801/ /pubmed/16368230 http://dx.doi.org/10.1016/j.coi.2005.11.014 Text en Copyright © 2005 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Takahashi, Kazue
Ip, WK Eddie
Michelow, Ian C
Ezekowitz, R Alan B
The mannose-binding lectin: a prototypic pattern recognition molecule
title The mannose-binding lectin: a prototypic pattern recognition molecule
title_full The mannose-binding lectin: a prototypic pattern recognition molecule
title_fullStr The mannose-binding lectin: a prototypic pattern recognition molecule
title_full_unstemmed The mannose-binding lectin: a prototypic pattern recognition molecule
title_short The mannose-binding lectin: a prototypic pattern recognition molecule
title_sort mannose-binding lectin: a prototypic pattern recognition molecule
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126801/
https://www.ncbi.nlm.nih.gov/pubmed/16368230
http://dx.doi.org/10.1016/j.coi.2005.11.014
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