The medicinal chemistry of Chikungunya virus

Arthropod-borne viruses (arboviruses) are an important threat to human and animal health globally. Among these, zoonotic diseases account for billions of cases of human illness and millions of deaths every year, representing an increasing public health problem. Chikungunya virus belongs to the genus...

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Detalles Bibliográficos
Autores principales: da Silva-Júnior, Edeildo F., Leoncini, Giovanni O., Rodrigues, Érica E.S., Aquino, Thiago M., Araújo-Júnior, João X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126832/
https://www.ncbi.nlm.nih.gov/pubmed/28689975
http://dx.doi.org/10.1016/j.bmc.2017.06.049
Descripción
Sumario:Arthropod-borne viruses (arboviruses) are an important threat to human and animal health globally. Among these, zoonotic diseases account for billions of cases of human illness and millions of deaths every year, representing an increasing public health problem. Chikungunya virus belongs to the genus Alphavirus of the family Togariridae, and is transmitted mainly by the bite of female mosquitoes of the Aedes aegypti and/or A. albopictus species. The focus of this review will be on the medicinal chemistry of Chikungunya virus, including synthetic and natural products, as well as rationally designed compounds.

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