La BPCO : une maladie qui commence précocement

This general review deals with the mechanisms which underlie the genetic factors in COPD. Many cellular and biochemical mechanisms occur in bronchial inflammation. We present the experimental models of COPD, insisting on the importance of oxydative stress, and on recent knowledge about the lung micr...

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Detalles Bibliográficos
Autores principales: Margelidon-Cozzolino, V., Chbini, K., Freymond, N., Devouassoux, G., Belaaouaj, A., Pacheco, Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2016
Materias:
Revue Générale
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126852/
https://www.ncbi.nlm.nih.gov/pubmed/26657351
http://dx.doi.org/10.1016/j.pneumo.2015.08.002
Descripción
Sumario:This general review deals with the mechanisms which underlie the genetic factors in COPD. Many cellular and biochemical mechanisms occur in bronchial inflammation. We present the experimental models of COPD, insisting on the importance of oxydative stress, and on recent knowledge about the lung microbiome. Starting from this pathophysiology basis, we show how various genetic targets are able to interfere with the disease model. Thanks to these genetic targets, new markers in exhaled breath condensates and new drug targets are rising.

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