La BPCO : une maladie qui commence précocement

This general review deals with the mechanisms which underlie the genetic factors in COPD. Many cellular and biochemical mechanisms occur in bronchial inflammation. We present the experimental models of COPD, insisting on the importance of oxydative stress, and on recent knowledge about the lung micr...

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Detalles Bibliográficos
Autores principales: Margelidon-Cozzolino, V., Chbini, K., Freymond, N., Devouassoux, G., Belaaouaj, A., Pacheco, Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2016
Materias:
Revue Générale
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126852/
https://www.ncbi.nlm.nih.gov/pubmed/26657351
http://dx.doi.org/10.1016/j.pneumo.2015.08.002
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author Margelidon-Cozzolino, V.
Chbini, K.
Freymond, N.
Devouassoux, G.
Belaaouaj, A.
Pacheco, Y.
author_facet Margelidon-Cozzolino, V.
Chbini, K.
Freymond, N.
Devouassoux, G.
Belaaouaj, A.
Pacheco, Y.
author_sort Margelidon-Cozzolino, V.
collection PubMed
description This general review deals with the mechanisms which underlie the genetic factors in COPD. Many cellular and biochemical mechanisms occur in bronchial inflammation. We present the experimental models of COPD, insisting on the importance of oxydative stress, and on recent knowledge about the lung microbiome. Starting from this pathophysiology basis, we show how various genetic targets are able to interfere with the disease model. Thanks to these genetic targets, new markers in exhaled breath condensates and new drug targets are rising.
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spelling pubmed-71268522020-04-08 La BPCO : une maladie qui commence précocement Margelidon-Cozzolino, V. Chbini, K. Freymond, N. Devouassoux, G. Belaaouaj, A. Pacheco, Y. Rev Pneumol Clin Revue Générale This general review deals with the mechanisms which underlie the genetic factors in COPD. Many cellular and biochemical mechanisms occur in bronchial inflammation. We present the experimental models of COPD, insisting on the importance of oxydative stress, and on recent knowledge about the lung microbiome. Starting from this pathophysiology basis, we show how various genetic targets are able to interfere with the disease model. Thanks to these genetic targets, new markers in exhaled breath condensates and new drug targets are rising. Elsevier Masson SAS. 2016-02 2015-12-03 /pmc/articles/PMC7126852/ /pubmed/26657351 http://dx.doi.org/10.1016/j.pneumo.2015.08.002 Text en Copyright © 2015 Elsevier Masson SAS. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Revue Générale
Margelidon-Cozzolino, V.
Chbini, K.
Freymond, N.
Devouassoux, G.
Belaaouaj, A.
Pacheco, Y.
La BPCO : une maladie qui commence précocement
title La BPCO : une maladie qui commence précocement
title_full La BPCO : une maladie qui commence précocement
title_fullStr La BPCO : une maladie qui commence précocement
title_full_unstemmed La BPCO : une maladie qui commence précocement
title_short La BPCO : une maladie qui commence précocement
title_sort la bpco : une maladie qui commence précocement
topic Revue Générale
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126852/
https://www.ncbi.nlm.nih.gov/pubmed/26657351
http://dx.doi.org/10.1016/j.pneumo.2015.08.002
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