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Dieckol, a SARS-CoV 3CL(pro) inhibitor, isolated from the edible brown algae Ecklonia cava
Phlorotannins have been isolated and are the first of their type showing competitively inhibitory activity toward SARS-CoV 3CLpro. Dieckol showed the most potent SARS-CoV 3CLpro trans/cis-cleavage inhibitory effects with high association rate. [Figure: see text]
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Ltd.
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126891/ https://www.ncbi.nlm.nih.gov/pubmed/23647823 http://dx.doi.org/10.1016/j.bmc.2013.04.026 |
| _version_ | 1783516242670256128 |
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| author | Park, Ji-Young Kim, Jang Hoon Kwon, Jung Min Kwon, Hyung-Jun Jeong, Hyung Jae Kim, Young Min Kim, Doman Lee, Woo Song Ryu, Young Bae |
| author_facet | Park, Ji-Young Kim, Jang Hoon Kwon, Jung Min Kwon, Hyung-Jun Jeong, Hyung Jae Kim, Young Min Kim, Doman Lee, Woo Song Ryu, Young Bae |
| author_sort | Park, Ji-Young |
| collection | PubMed |
| description | Phlorotannins have been isolated and are the first of their type showing competitively inhibitory activity toward SARS-CoV 3CLpro. Dieckol showed the most potent SARS-CoV 3CLpro trans/cis-cleavage inhibitory effects with high association rate. [Figure: see text] |
| format | Online Article Text |
| id | pubmed-7126891 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2013 |
| publisher | Elsevier Ltd. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-71268912020-04-08 Dieckol, a SARS-CoV 3CL(pro) inhibitor, isolated from the edible brown algae Ecklonia cava Park, Ji-Young Kim, Jang Hoon Kwon, Jung Min Kwon, Hyung-Jun Jeong, Hyung Jae Kim, Young Min Kim, Doman Lee, Woo Song Ryu, Young Bae Bioorg Med Chem Article Phlorotannins have been isolated and are the first of their type showing competitively inhibitory activity toward SARS-CoV 3CLpro. Dieckol showed the most potent SARS-CoV 3CLpro trans/cis-cleavage inhibitory effects with high association rate. [Figure: see text] Elsevier Ltd. 2013-07-01 2013-04-22 /pmc/articles/PMC7126891/ /pubmed/23647823 http://dx.doi.org/10.1016/j.bmc.2013.04.026 Text en Copyright © 2013 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
| spellingShingle | Article Park, Ji-Young Kim, Jang Hoon Kwon, Jung Min Kwon, Hyung-Jun Jeong, Hyung Jae Kim, Young Min Kim, Doman Lee, Woo Song Ryu, Young Bae Dieckol, a SARS-CoV 3CL(pro) inhibitor, isolated from the edible brown algae Ecklonia cava |
| title | Dieckol, a SARS-CoV 3CL(pro) inhibitor, isolated from the edible brown algae Ecklonia cava |
| title_full | Dieckol, a SARS-CoV 3CL(pro) inhibitor, isolated from the edible brown algae Ecklonia cava |
| title_fullStr | Dieckol, a SARS-CoV 3CL(pro) inhibitor, isolated from the edible brown algae Ecklonia cava |
| title_full_unstemmed | Dieckol, a SARS-CoV 3CL(pro) inhibitor, isolated from the edible brown algae Ecklonia cava |
| title_short | Dieckol, a SARS-CoV 3CL(pro) inhibitor, isolated from the edible brown algae Ecklonia cava |
| title_sort | dieckol, a sars-cov 3cl(pro) inhibitor, isolated from the edible brown algae ecklonia cava |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126891/ https://www.ncbi.nlm.nih.gov/pubmed/23647823 http://dx.doi.org/10.1016/j.bmc.2013.04.026 |
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