The potential of molecular diagnostics and serum procalcitonin levels to change the antibiotic management of community-acquired pneumonia

Two diagnostic bundles were compared in 127 evaluable patients admitted with community-acquired pneumonia (CAP). Diagnostic modalities in all patients included cultures of sputum (if obtainable) and blood, urine for detection of the antigens of Streptococcus pneumoniae and Legionella pneumophila, an...

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Autores principales: Gilbert, David, Gelfer, Gita, Wang, Lian, Myers, Jillian, Bajema, Kristina, Johnston, Michael, Leggett, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2016
Materias:
Clinical Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126930/
https://www.ncbi.nlm.nih.gov/pubmed/27377675
http://dx.doi.org/10.1016/j.diagmicrobio.2016.06.008
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author Gilbert, David
Gelfer, Gita
Wang, Lian
Myers, Jillian
Bajema, Kristina
Johnston, Michael
Leggett, James
author_facet Gilbert, David
Gelfer, Gita
Wang, Lian
Myers, Jillian
Bajema, Kristina
Johnston, Michael
Leggett, James
author_sort Gilbert, David
collection PubMed
description Two diagnostic bundles were compared in 127 evaluable patients admitted with community-acquired pneumonia (CAP). Diagnostic modalities in all patients included cultures of sputum (if obtainable) and blood, urine for detection of the antigens of Streptococcus pneumoniae and Legionella pneumophila, and nasal swabs for PCR probes for S. pneumoniae and Staphylococcus aureus. At least one procalcitonin level was measured in all patients. For virus detection, patients were randomized to either a 5-virus, lab-generated PCR panel or the broader and faster FilmArray PCR panel. Overall, an etiologic diagnosis was established in 71% of the patients. A respiratory virus was detected in 39%. The potential for improved antibiotic stewardship was evident in 25 patients with only detectable respiratory virus and normal levels of PCT.
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spelling pubmed-71269302020-04-08 The potential of molecular diagnostics and serum procalcitonin levels to change the antibiotic management of community-acquired pneumonia Gilbert, David Gelfer, Gita Wang, Lian Myers, Jillian Bajema, Kristina Johnston, Michael Leggett, James Diagn Microbiol Infect Dis Clinical Studies Two diagnostic bundles were compared in 127 evaluable patients admitted with community-acquired pneumonia (CAP). Diagnostic modalities in all patients included cultures of sputum (if obtainable) and blood, urine for detection of the antigens of Streptococcus pneumoniae and Legionella pneumophila, and nasal swabs for PCR probes for S. pneumoniae and Staphylococcus aureus. At least one procalcitonin level was measured in all patients. For virus detection, patients were randomized to either a 5-virus, lab-generated PCR panel or the broader and faster FilmArray PCR panel. Overall, an etiologic diagnosis was established in 71% of the patients. A respiratory virus was detected in 39%. The potential for improved antibiotic stewardship was evident in 25 patients with only detectable respiratory virus and normal levels of PCT. Elsevier Inc. 2016-09 2016-06-15 /pmc/articles/PMC7126930/ /pubmed/27377675 http://dx.doi.org/10.1016/j.diagmicrobio.2016.06.008 Text en © 2016 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Clinical Studies
Gilbert, David
Gelfer, Gita
Wang, Lian
Myers, Jillian
Bajema, Kristina
Johnston, Michael
Leggett, James
The potential of molecular diagnostics and serum procalcitonin levels to change the antibiotic management of community-acquired pneumonia
title The potential of molecular diagnostics and serum procalcitonin levels to change the antibiotic management of community-acquired pneumonia
title_full The potential of molecular diagnostics and serum procalcitonin levels to change the antibiotic management of community-acquired pneumonia
title_fullStr The potential of molecular diagnostics and serum procalcitonin levels to change the antibiotic management of community-acquired pneumonia
title_full_unstemmed The potential of molecular diagnostics and serum procalcitonin levels to change the antibiotic management of community-acquired pneumonia
title_short The potential of molecular diagnostics and serum procalcitonin levels to change the antibiotic management of community-acquired pneumonia
title_sort potential of molecular diagnostics and serum procalcitonin levels to change the antibiotic management of community-acquired pneumonia
topic Clinical Studies
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126930/
https://www.ncbi.nlm.nih.gov/pubmed/27377675
http://dx.doi.org/10.1016/j.diagmicrobio.2016.06.008
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