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Synthesis of 5-isoxazol-5-yl-2′-deoxyuridines exhibiting antiviral activity against HSV and several RNA viruses

This paper describes a simple method for synthesizing a small library of 5-isoxazol-5-yl-2′-deoxyuridines from 5-iodo-2′-deoxyuridine. Nitrile oxides were generated in situ from oximes using a commercial bleaching agent; their cycloaddition with 5-ethynyl-2′-deoxyuridine yielded isoxazoles possessin...

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Detalles Bibliográficos
Autores principales:	Lee, Yoon-Suk, Park, Sun Min, Kim, Byeang Hyean
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Published by Elsevier Ltd. 2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126966/ https://www.ncbi.nlm.nih.gov/pubmed/19147352 http://dx.doi.org/10.1016/j.bmcl.2008.12.103

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