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Advances in the diagnosis of key gastrointestinal nematode infections of livestock, with an emphasis on small ruminants
Parasitic nematodes (roundworms) of livestock have major economic impact globally. In spite of the diseases caused by these nematodes and some advances in the design of new therapeutic agents (anthelmintics) and attempts to develop vaccines against some of them, there has been limited progress in th...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126997/ https://www.ncbi.nlm.nih.gov/pubmed/23376340 http://dx.doi.org/10.1016/j.biotechadv.2013.01.008 |
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author | Roeber, Florian Jex, Aaron R. Gasser, Robin B. |
author_facet | Roeber, Florian Jex, Aaron R. Gasser, Robin B. |
author_sort | Roeber, Florian |
collection | PubMed |
description | Parasitic nematodes (roundworms) of livestock have major economic impact globally. In spite of the diseases caused by these nematodes and some advances in the design of new therapeutic agents (anthelmintics) and attempts to develop vaccines against some of them, there has been limited progress in the establishment of practical diagnostic techniques. The specific and sensitive diagnosis of gastrointestinal nematode infections of livestock underpins effective disease control, which is highly relevant now that anthelmintic resistance (AR) is a major problem. Traditional diagnostic techniques have major constraints, in terms of sensitivity and specificity. The purpose of this article is to provide a brief background on gastrointestinal nematodes (Strongylida) of livestock and their control; to summarize conventional methods used for the diagnosis and discuss their constraints; to review key molecular-diagnostic methods and recent progress in the development of advanced amplification-based and sequencing technologies, and their implications for epidemiological investigations and the control of parasitic diseases. |
format | Online Article Text |
id | pubmed-7126997 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71269972020-04-08 Advances in the diagnosis of key gastrointestinal nematode infections of livestock, with an emphasis on small ruminants Roeber, Florian Jex, Aaron R. Gasser, Robin B. Biotechnol Adv Article Parasitic nematodes (roundworms) of livestock have major economic impact globally. In spite of the diseases caused by these nematodes and some advances in the design of new therapeutic agents (anthelmintics) and attempts to develop vaccines against some of them, there has been limited progress in the establishment of practical diagnostic techniques. The specific and sensitive diagnosis of gastrointestinal nematode infections of livestock underpins effective disease control, which is highly relevant now that anthelmintic resistance (AR) is a major problem. Traditional diagnostic techniques have major constraints, in terms of sensitivity and specificity. The purpose of this article is to provide a brief background on gastrointestinal nematodes (Strongylida) of livestock and their control; to summarize conventional methods used for the diagnosis and discuss their constraints; to review key molecular-diagnostic methods and recent progress in the development of advanced amplification-based and sequencing technologies, and their implications for epidemiological investigations and the control of parasitic diseases. Elsevier Inc. 2013-12 2013-01-30 /pmc/articles/PMC7126997/ /pubmed/23376340 http://dx.doi.org/10.1016/j.biotechadv.2013.01.008 Text en Copyright © 2013 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Roeber, Florian Jex, Aaron R. Gasser, Robin B. Advances in the diagnosis of key gastrointestinal nematode infections of livestock, with an emphasis on small ruminants |
title | Advances in the diagnosis of key gastrointestinal nematode infections of livestock, with an emphasis on small ruminants |
title_full | Advances in the diagnosis of key gastrointestinal nematode infections of livestock, with an emphasis on small ruminants |
title_fullStr | Advances in the diagnosis of key gastrointestinal nematode infections of livestock, with an emphasis on small ruminants |
title_full_unstemmed | Advances in the diagnosis of key gastrointestinal nematode infections of livestock, with an emphasis on small ruminants |
title_short | Advances in the diagnosis of key gastrointestinal nematode infections of livestock, with an emphasis on small ruminants |
title_sort | advances in the diagnosis of key gastrointestinal nematode infections of livestock, with an emphasis on small ruminants |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126997/ https://www.ncbi.nlm.nih.gov/pubmed/23376340 http://dx.doi.org/10.1016/j.biotechadv.2013.01.008 |
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