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Comparative efficacy of diclazuril (Vecoxan(®)) and toltrazuril (Baycox bovis(®)) against natural infections of Eimeria bovis and Eimeria zuernii in French calves
A blinded, randomized, controlled, multi-centric field study was conducted on French dairy farms (n = 9) to evaluate the long term efficacy of metaphylactic, single oral treatments with either 1 mg/kg body weight (BW) of diclazuril (Vecoxan(®)), or 15 mg/kg BW of toltrazuril (Baycox(®)) against natu...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Authors. Published by Elsevier B.V.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127088/ https://www.ncbi.nlm.nih.gov/pubmed/25458561 http://dx.doi.org/10.1016/j.vetpar.2014.10.003 |
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author | Philippe, P. Alzieu, J.P. Taylor, M.A. Dorchies, Ph. |
author_facet | Philippe, P. Alzieu, J.P. Taylor, M.A. Dorchies, Ph. |
author_sort | Philippe, P. |
collection | PubMed |
description | A blinded, randomized, controlled, multi-centric field study was conducted on French dairy farms (n = 9) to evaluate the long term efficacy of metaphylactic, single oral treatments with either 1 mg/kg body weight (BW) of diclazuril (Vecoxan(®)), or 15 mg/kg BW of toltrazuril (Baycox(®)) against natural infections with Eimeria zuernii and/or Eimeria bovis, compared to untreated control animals. A total of 199 calves from nine commercial farms aged between 21 and 55 days old at the start of study were included and randomly allocated to one of three groups. Calves on all farms were observed for a period of 78 days post treatment, using both parasitological (oocyst excretion), and clinical parameters (faecal score and body weight). The assessment of efficacy was based on both control of oocyst excretion, and on the average daily weight gains throughout the study. During the whole study period, the mean number of days with diarrhoea (≥2) was similar (0.7 days) between treated groups. Excretion in the untreated group peaked at 21 days after treatment. In both the diclazuril and toltrazuril-treated groups, mean oocyst excretion decreased dramatically in the five days following treatment. Thereafter, particularly towards the end of the study period, oocyst counts and percentage levels of E. zuernii were highest in the toltrazuril-treated group. In pooled data from all trial sites, the average daily weight gain was significantly (p = 0.01) higher (+0.057 kg/day) in the diclazuril group when compared to the toltrazuril group, and the average body weight gain of the diclazuril treated group was 4.4 kg higher than the toltrazuril group. On eight of the nine trial sites, the average daily gain was greater in the diclazuril group than in the toltrazuril group. This study demonstrates that, over an extended observation period of 78 days, metaphylactic treatment with both diclazuril and toltrazuril reduces the impact of coccidiosis, but greater performance benefits based on average daily weight gains, were achieved following the use of diclazuril. |
format | Online Article Text |
id | pubmed-7127088 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | The Authors. Published by Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71270882020-04-08 Comparative efficacy of diclazuril (Vecoxan(®)) and toltrazuril (Baycox bovis(®)) against natural infections of Eimeria bovis and Eimeria zuernii in French calves Philippe, P. Alzieu, J.P. Taylor, M.A. Dorchies, Ph. Vet Parasitol Article A blinded, randomized, controlled, multi-centric field study was conducted on French dairy farms (n = 9) to evaluate the long term efficacy of metaphylactic, single oral treatments with either 1 mg/kg body weight (BW) of diclazuril (Vecoxan(®)), or 15 mg/kg BW of toltrazuril (Baycox(®)) against natural infections with Eimeria zuernii and/or Eimeria bovis, compared to untreated control animals. A total of 199 calves from nine commercial farms aged between 21 and 55 days old at the start of study were included and randomly allocated to one of three groups. Calves on all farms were observed for a period of 78 days post treatment, using both parasitological (oocyst excretion), and clinical parameters (faecal score and body weight). The assessment of efficacy was based on both control of oocyst excretion, and on the average daily weight gains throughout the study. During the whole study period, the mean number of days with diarrhoea (≥2) was similar (0.7 days) between treated groups. Excretion in the untreated group peaked at 21 days after treatment. In both the diclazuril and toltrazuril-treated groups, mean oocyst excretion decreased dramatically in the five days following treatment. Thereafter, particularly towards the end of the study period, oocyst counts and percentage levels of E. zuernii were highest in the toltrazuril-treated group. In pooled data from all trial sites, the average daily weight gain was significantly (p = 0.01) higher (+0.057 kg/day) in the diclazuril group when compared to the toltrazuril group, and the average body weight gain of the diclazuril treated group was 4.4 kg higher than the toltrazuril group. On eight of the nine trial sites, the average daily gain was greater in the diclazuril group than in the toltrazuril group. This study demonstrates that, over an extended observation period of 78 days, metaphylactic treatment with both diclazuril and toltrazuril reduces the impact of coccidiosis, but greater performance benefits based on average daily weight gains, were achieved following the use of diclazuril. The Authors. Published by Elsevier B.V. 2014-12-15 2014-10-20 /pmc/articles/PMC7127088/ /pubmed/25458561 http://dx.doi.org/10.1016/j.vetpar.2014.10.003 Text en © 2014 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Philippe, P. Alzieu, J.P. Taylor, M.A. Dorchies, Ph. Comparative efficacy of diclazuril (Vecoxan(®)) and toltrazuril (Baycox bovis(®)) against natural infections of Eimeria bovis and Eimeria zuernii in French calves |
title | Comparative efficacy of diclazuril (Vecoxan(®)) and toltrazuril (Baycox bovis(®)) against natural infections of Eimeria bovis and Eimeria zuernii in French calves |
title_full | Comparative efficacy of diclazuril (Vecoxan(®)) and toltrazuril (Baycox bovis(®)) against natural infections of Eimeria bovis and Eimeria zuernii in French calves |
title_fullStr | Comparative efficacy of diclazuril (Vecoxan(®)) and toltrazuril (Baycox bovis(®)) against natural infections of Eimeria bovis and Eimeria zuernii in French calves |
title_full_unstemmed | Comparative efficacy of diclazuril (Vecoxan(®)) and toltrazuril (Baycox bovis(®)) against natural infections of Eimeria bovis and Eimeria zuernii in French calves |
title_short | Comparative efficacy of diclazuril (Vecoxan(®)) and toltrazuril (Baycox bovis(®)) against natural infections of Eimeria bovis and Eimeria zuernii in French calves |
title_sort | comparative efficacy of diclazuril (vecoxan(®)) and toltrazuril (baycox bovis(®)) against natural infections of eimeria bovis and eimeria zuernii in french calves |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127088/ https://www.ncbi.nlm.nih.gov/pubmed/25458561 http://dx.doi.org/10.1016/j.vetpar.2014.10.003 |
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