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Pathogenic role of HMGB1 in SARS?

High mobility group box 1 protein (HMGB1) is released by necrotic cells or activated macrophages/monocytes, and functions as a late mediator of lethal systemic and local pulmonary inflammation. Passive immunization with anti-HMGB1 antibodies confers significant protection against lethal endotoxemia,...

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Detalles Bibliográficos
Autores principales: Chen, Guoqian, Chen, Da-zhi, Li, Jianhua, Czura, Christopher J., Tracey, Kevin J., Sama, Andrew E., Wang, Haichao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127179/
https://www.ncbi.nlm.nih.gov/pubmed/15325019
http://dx.doi.org/10.1016/j.mehy.2004.01.037
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author Chen, Guoqian
Chen, Da-zhi
Li, Jianhua
Czura, Christopher J.
Tracey, Kevin J.
Sama, Andrew E.
Wang, Haichao
author_facet Chen, Guoqian
Chen, Da-zhi
Li, Jianhua
Czura, Christopher J.
Tracey, Kevin J.
Sama, Andrew E.
Wang, Haichao
author_sort Chen, Guoqian
collection PubMed
description High mobility group box 1 protein (HMGB1) is released by necrotic cells or activated macrophages/monocytes, and functions as a late mediator of lethal systemic and local pulmonary inflammation. Passive immunization with anti-HMGB1 antibodies confers significant protection against lethal endotoxemia, sepsis, and acute lung injury, even when antibodies are administered after the onset of these diseases. In light of observations that three Chinese herbal formulations recommended for treatment of severe acute respiratory syndrome (SARS) specifically inhibited the release of HMGB1 from innate immune cells, we hypothesize that HMGB1 might occupy a pathogenic role in SARS by mediating an injurious pulmonary inflammatory response.
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spelling pubmed-71271792020-04-08 Pathogenic role of HMGB1 in SARS? Chen, Guoqian Chen, Da-zhi Li, Jianhua Czura, Christopher J. Tracey, Kevin J. Sama, Andrew E. Wang, Haichao Med Hypotheses Article High mobility group box 1 protein (HMGB1) is released by necrotic cells or activated macrophages/monocytes, and functions as a late mediator of lethal systemic and local pulmonary inflammation. Passive immunization with anti-HMGB1 antibodies confers significant protection against lethal endotoxemia, sepsis, and acute lung injury, even when antibodies are administered after the onset of these diseases. In light of observations that three Chinese herbal formulations recommended for treatment of severe acute respiratory syndrome (SARS) specifically inhibited the release of HMGB1 from innate immune cells, we hypothesize that HMGB1 might occupy a pathogenic role in SARS by mediating an injurious pulmonary inflammatory response. Elsevier Ltd. 2004 2004-04-30 /pmc/articles/PMC7127179/ /pubmed/15325019 http://dx.doi.org/10.1016/j.mehy.2004.01.037 Text en Copyright © 2004 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Chen, Guoqian
Chen, Da-zhi
Li, Jianhua
Czura, Christopher J.
Tracey, Kevin J.
Sama, Andrew E.
Wang, Haichao
Pathogenic role of HMGB1 in SARS?
title Pathogenic role of HMGB1 in SARS?
title_full Pathogenic role of HMGB1 in SARS?
title_fullStr Pathogenic role of HMGB1 in SARS?
title_full_unstemmed Pathogenic role of HMGB1 in SARS?
title_short Pathogenic role of HMGB1 in SARS?
title_sort pathogenic role of hmgb1 in sars?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127179/
https://www.ncbi.nlm.nih.gov/pubmed/15325019
http://dx.doi.org/10.1016/j.mehy.2004.01.037
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