Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof

HCMV infection represents a life-threatening condition for immunocompromised patients and newborn infants and novel anti-HCMV agents are clearly needed. In this regard, a series of 1-[ω-(phenoxy)alkyl]uracil derivatives were synthesized and examined for antiviral properties. Compounds 17, 20, 24 and...

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Autores principales: Novikov, Mikhail S., Babkov, Denis A., Paramonova, Maria P., Khandazhinskaya, Anastasia L., Ozerov, Alexander A., Chizhov, Alexander O., Andrei, Graciela, Snoeck, Robert, Balzarini, Jan, Seley-Radtke, Katherine L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127185/
https://www.ncbi.nlm.nih.gov/pubmed/23743443
http://dx.doi.org/10.1016/j.bmc.2013.05.009
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author Novikov, Mikhail S.
Babkov, Denis A.
Paramonova, Maria P.
Khandazhinskaya, Anastasia L.
Ozerov, Alexander A.
Chizhov, Alexander O.
Andrei, Graciela
Snoeck, Robert
Balzarini, Jan
Seley-Radtke, Katherine L.
author_facet Novikov, Mikhail S.
Babkov, Denis A.
Paramonova, Maria P.
Khandazhinskaya, Anastasia L.
Ozerov, Alexander A.
Chizhov, Alexander O.
Andrei, Graciela
Snoeck, Robert
Balzarini, Jan
Seley-Radtke, Katherine L.
author_sort Novikov, Mikhail S.
collection PubMed
description HCMV infection represents a life-threatening condition for immunocompromised patients and newborn infants and novel anti-HCMV agents are clearly needed. In this regard, a series of 1-[ω-(phenoxy)alkyl]uracil derivatives were synthesized and examined for antiviral properties. Compounds 17, 20, 24 and 28 were found to exhibit highly specific and promising inhibitory activity against HCMV replication in HEL cell cultures with EC(50) values within 5.5–12 μM range. Further studies should be undertaken to elucidate the mechanism of action of these compounds and the structure–activity relationship for the linker region.
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spelling pubmed-71271852020-04-08 Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof Novikov, Mikhail S. Babkov, Denis A. Paramonova, Maria P. Khandazhinskaya, Anastasia L. Ozerov, Alexander A. Chizhov, Alexander O. Andrei, Graciela Snoeck, Robert Balzarini, Jan Seley-Radtke, Katherine L. Bioorg Med Chem Article HCMV infection represents a life-threatening condition for immunocompromised patients and newborn infants and novel anti-HCMV agents are clearly needed. In this regard, a series of 1-[ω-(phenoxy)alkyl]uracil derivatives were synthesized and examined for antiviral properties. Compounds 17, 20, 24 and 28 were found to exhibit highly specific and promising inhibitory activity against HCMV replication in HEL cell cultures with EC(50) values within 5.5–12 μM range. Further studies should be undertaken to elucidate the mechanism of action of these compounds and the structure–activity relationship for the linker region. Elsevier Ltd. 2013-07-15 2013-05-16 /pmc/articles/PMC7127185/ /pubmed/23743443 http://dx.doi.org/10.1016/j.bmc.2013.05.009 Text en Copyright © 2013 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Novikov, Mikhail S.
Babkov, Denis A.
Paramonova, Maria P.
Khandazhinskaya, Anastasia L.
Ozerov, Alexander A.
Chizhov, Alexander O.
Andrei, Graciela
Snoeck, Robert
Balzarini, Jan
Seley-Radtke, Katherine L.
Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof
title Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof
title_full Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof
title_fullStr Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof
title_full_unstemmed Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof
title_short Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof
title_sort synthesis and anti-hcmv activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127185/
https://www.ncbi.nlm.nih.gov/pubmed/23743443
http://dx.doi.org/10.1016/j.bmc.2013.05.009
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