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9-[2-(R)-(Phosphonomethoxy)propyl]-2,6-diaminopurine (R)-PMPDAP and its prodrugs: Optimized preparation, including identification of by-products formed, and antiviral evaluation in vitro

New large-scale synthetic approach to antiretroviral agent 9-[2-(R)-(phosphonomethoxy)propyl]-2,6-diaminopurine, (R)-PMPDAP, was developed. Reaction of (R)-propanediol carbonate with 2,6-diaminopurine afforded exclusively (R)-9-(2-hydroxypropyl)-2,6-diaminopurine which was subsequently used for intr...

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Detalles Bibliográficos
Autores principales:	Krečmerová, Marcela, Jansa, Petr, Dračínský, Martin, Sázelová, Petra, Kašička, Václav, Neyts, Johan, Auwerx, Joeri, Kiss, Eleonóra, Goris, Nesya, Stepan, George, Janeba, Zlatko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Ltd. 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127208/ https://www.ncbi.nlm.nih.gov/pubmed/23375089 http://dx.doi.org/10.1016/j.bmc.2012.12.044

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