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Flaviviral methyltransferase/RNA interaction: Structural basis for enzyme inhibition

Flaviviruses are the causative agents of severe diseases such as Dengue or Yellow fever. The replicative machinery used by the virus is based on few enzymes including a methyltransferase, located in the N-terminal domain of the NS5 protein. Flaviviral methyltransferases are involved in the last two...

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Detalles Bibliográficos
Autores principales: Milani, Mario, Mastrangelo, Eloise, Bollati, Michela, Selisko, Barbara, Decroly, Etienne, Bouvet, Mickaël, Canard, Bruno, Bolognesi, Martino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127253/
https://www.ncbi.nlm.nih.gov/pubmed/19501254
http://dx.doi.org/10.1016/j.antiviral.2009.03.001