Regioselective synthesis of 6-substituted-2-amino-5-bromo-4(3H)-pyrimidinones and evaluation of their antiviral activity

A series of 2-amino-5-bromo-4(3H)-pyrimidinone derivatives bearing different substituents at the C-6 position were synthesized using a highly regioselective lithiation–substitution protocol, and the effect of structural variation at the C-6 position on their antiviral activity in cell culture was ev...

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Detalles Bibliográficos
Autores principales: Singh, Kamaljit, Singh, Kawaljit, Balzarini, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127258/
https://www.ncbi.nlm.nih.gov/pubmed/23911856
http://dx.doi.org/10.1016/j.ejmech.2013.06.036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127258/
https://www.ncbi.nlm.nih.gov/pubmed/23911856
http://dx.doi.org/10.1016/j.ejmech.2013.06.036

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