Synthesis and biological evaluation of prodrugs of 2-fluoro-2-deoxyribose-1-phosphate and 2,2-difluoro-2-deoxyribose-1-phosphate

We report in this Letter the synthesis of prodrugs of 2-fluoro-2-deoxyarabinose-1-phosphate and 2,2-difluoro-2-deoxyribose-1-phosphate. We demonstrate the difficulty of realising a phosphorylation step on the anomeric position of 2-deoxyribose, and we discover that introduction of fluorine atoms on...

Descripción completa

Detalles Bibliográficos
Autores principales: Hamon, Nadege, Quintiliani, Maurizio, Balzarini, Jan, McGuigan, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127338/
https://www.ncbi.nlm.nih.gov/pubmed/23541671
http://dx.doi.org/10.1016/j.bmcl.2013.02.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127338/
https://www.ncbi.nlm.nih.gov/pubmed/23541671
http://dx.doi.org/10.1016/j.bmcl.2013.02.117

Ejemplares similares