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Synthesis and biological evaluation of prodrugs of 2-fluoro-2-deoxyribose-1-phosphate and 2,2-difluoro-2-deoxyribose-1-phosphate

We report in this Letter the synthesis of prodrugs of 2-fluoro-2-deoxyarabinose-1-phosphate and 2,2-difluoro-2-deoxyribose-1-phosphate. We demonstrate the difficulty of realising a phosphorylation step on the anomeric position of 2-deoxyribose, and we discover that introduction of fluorine atoms on...

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Detalles Bibliográficos
Autores principales:	Hamon, Nadege, Quintiliani, Maurizio, Balzarini, Jan, McGuigan, Christopher
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Published by Elsevier Ltd. 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127338/ https://www.ncbi.nlm.nih.gov/pubmed/23541671 http://dx.doi.org/10.1016/j.bmcl.2013.02.117

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