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Chitosan-modified poly(d,l-lactide-co-glycolide) nanospheres for improving siRNA delivery and gene-silencing effects

Chitosan (CS) surface-modified poly(d,l-lactide-co-glycolide) (PLGA) nanospheres (NS) for a siRNA delivery system were evaluated in vitro. siRNA-loaded PLGA NS were prepared by an emulsion solvent diffusion (ESD) method, and the physicochemical properties of NS were investigated. The level of target...

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Detalles Bibliográficos
Autores principales:	Tahara, Kohei, Yamamoto, Hiromitsu, Hirashima, Naohide, Kawashima, Yoshiaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier B.V. 2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127408/ https://www.ncbi.nlm.nih.gov/pubmed/20034563 http://dx.doi.org/10.1016/j.ejpb.2009.12.007

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