The 2b protein as a minor structural component of PRRSV()

Porcine reproductive and respiratory syndrome virus (PRRSV) ORF2 contains an internal ORF that codes for a small non-glycosylated protein known as 2b. Previous work had identified the presence of a 10 kDa 2b protein in virus-infected cells and the induction of an anti-2b response in PRRSV-infected p...

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Detalles Bibliográficos
Autores principales: Wu, Wai-Hong, Fang, Ying, Rowland, Raymond R.R., Lawson, Steven R., Christopher-Hennings, Jane, Yoon, Kyoung-Jin, Nelson, Eric A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127422/
https://www.ncbi.nlm.nih.gov/pubmed/16095746
http://dx.doi.org/10.1016/j.virusres.2005.06.014
Descripción
Sumario:Porcine reproductive and respiratory syndrome virus (PRRSV) ORF2 contains an internal ORF that codes for a small non-glycosylated protein known as 2b. Previous work had identified the presence of a 10 kDa 2b protein in virus-infected cells and the induction of an anti-2b response in PRRSV-infected pigs, as well as a possible association of 2b with the virion (Wu et al., 2001, Virology 287:183–191). In this study, we utilized two experimental approaches, including the use of a 2b peptide-specific monoclonal antibody, to demonstrate that the PRRSV 2b protein is an integral component of the PRRSV virion. This study suggests that 2b in PRRSV is similar to the E protein in EAV and forms a minor structural component of the virion.

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