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Does form meet function in the coronavirus replicative organelle?

If we use the analogy of a virus as a living entity, then the replicative organelle is the part of the body where its metabolic and reproductive activities are concentrated. Recent studies have illuminated the intricately complex replicative organelles of coronaviruses, a group that includes the lar...

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Detalles Bibliográficos
Autores principales: Neuman, Benjamin W., Angelini, Megan M., Buchmeier, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127430/
https://www.ncbi.nlm.nih.gov/pubmed/25037114
http://dx.doi.org/10.1016/j.tim.2014.06.003
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author Neuman, Benjamin W.
Angelini, Megan M.
Buchmeier, Michael J.
author_facet Neuman, Benjamin W.
Angelini, Megan M.
Buchmeier, Michael J.
author_sort Neuman, Benjamin W.
collection PubMed
description If we use the analogy of a virus as a living entity, then the replicative organelle is the part of the body where its metabolic and reproductive activities are concentrated. Recent studies have illuminated the intricately complex replicative organelles of coronaviruses, a group that includes the largest known RNA virus genomes. This review takes a virus-centric look at the coronavirus replication transcription complex organelle in the context of the wider world of positive sense RNA viruses, examining how the mechanisms of protein expression and function act to produce the factories that power the viral replication cycle.
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spelling pubmed-71274302020-04-08 Does form meet function in the coronavirus replicative organelle? Neuman, Benjamin W. Angelini, Megan M. Buchmeier, Michael J. Trends Microbiol Review If we use the analogy of a virus as a living entity, then the replicative organelle is the part of the body where its metabolic and reproductive activities are concentrated. Recent studies have illuminated the intricately complex replicative organelles of coronaviruses, a group that includes the largest known RNA virus genomes. This review takes a virus-centric look at the coronavirus replication transcription complex organelle in the context of the wider world of positive sense RNA viruses, examining how the mechanisms of protein expression and function act to produce the factories that power the viral replication cycle. Elsevier Ltd. 2014-11 2014-07-15 /pmc/articles/PMC7127430/ /pubmed/25037114 http://dx.doi.org/10.1016/j.tim.2014.06.003 Text en Copyright © 2014 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Neuman, Benjamin W.
Angelini, Megan M.
Buchmeier, Michael J.
Does form meet function in the coronavirus replicative organelle?
title Does form meet function in the coronavirus replicative organelle?
title_full Does form meet function in the coronavirus replicative organelle?
title_fullStr Does form meet function in the coronavirus replicative organelle?
title_full_unstemmed Does form meet function in the coronavirus replicative organelle?
title_short Does form meet function in the coronavirus replicative organelle?
title_sort does form meet function in the coronavirus replicative organelle?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127430/
https://www.ncbi.nlm.nih.gov/pubmed/25037114
http://dx.doi.org/10.1016/j.tim.2014.06.003
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