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Structural effects on the phosphorylation of 3-substituted 1-β-d-ribofuranosyl-1,2,4-triazoles by human adenosine kinase

The conversion of ribavirin to the monophosphate by adenosine kinase is the rate-limiting step in activation of this broad spectrum antiviral drug. Variation of the 3-substituents in a series of bioisosteric and homologated 1-β-d-ribofuranosyl-1,2,4-triazoles has marked effects on activity with the...

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Detalles Bibliográficos
Autores principales:	Kumarapperuma, Sidath C., Sun, Yanjie, Jeselnik, Marjan, Chung, Kiwon, Parker, William B., Jonsson, Colleen B., Arterburn, Jeffrey B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Ltd. 2007
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127453/ https://www.ncbi.nlm.nih.gov/pubmed/17379518 http://dx.doi.org/10.1016/j.bmcl.2007.03.018

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