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Role of T cells in resistance to Theiler's virus infection()

Intracerebral infection of C57BL/10SNJ mice with Theiler's virus results in acute encephalitis with subsequent virus clearance and absence of spinal cord demyelination. In contrast, infection of SJL/J mice results in acute encephalitis, virus persistence, and immune-mediated demyelination. Thes...

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Detalles Bibliográficos
Autores principales: Rodriguez, Moses, Lindsley, Mark D., Pierce, Mabel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 1991
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127457/
https://www.ncbi.nlm.nih.gov/pubmed/1687607
http://dx.doi.org/10.1016/0882-4010(91)90031-5
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author Rodriguez, Moses
Lindsley, Mark D.
Pierce, Mabel L.
author_facet Rodriguez, Moses
Lindsley, Mark D.
Pierce, Mabel L.
author_sort Rodriguez, Moses
collection PubMed
description Intracerebral infection of C57BL/10SNJ mice with Theiler's virus results in acute encephalitis with subsequent virus clearance and absence of spinal cord demyelination. In contrast, infection of SJL/J mice results in acute encephalitis, virus persistence, and immune-mediated demyelination. These experiments examined the role of T-cell subsets in the in vivo immune response to Theiler's virus in resistant C57BL/10SNJ mice. Depletion of T-cell subsets with monoclonal antibodies (mAbs) directed at CD3 (pan-T-cell marker), CD4(+) (class II-restricted) or CD8(+) (class I-restricted) T cells resulted in increased frequency of paralysis and death as a result of acute encephalitis. Neuropathologic studies 10 days after infection demonstrated prominent necrosis, primarily in the pyramidal layer of hippocampus and in the thalamus of mice depleted of T-cell subsets. In immunosuppressed and infected C57BL/10SNJ mice, analysis of spinal cord sections 35 days after infection demonstrated small demyelinated lesions relatively devoid of inflammatory cells even though virus antigen could be detected by immunocytochemistry. Both CD4(+) and CD8(+) T cells are important in the resistance to infection with Theiler's virus in C57BL/10SNJ mice. However, subsequent spinal cord demyelination, to the extent observed in susceptible mice, depends on the presence of virus antigen persistence and a competent cellular immune response.
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spelling pubmed-71274572020-04-08 Role of T cells in resistance to Theiler's virus infection() Rodriguez, Moses Lindsley, Mark D. Pierce, Mabel L. Microb Pathog Article Intracerebral infection of C57BL/10SNJ mice with Theiler's virus results in acute encephalitis with subsequent virus clearance and absence of spinal cord demyelination. In contrast, infection of SJL/J mice results in acute encephalitis, virus persistence, and immune-mediated demyelination. These experiments examined the role of T-cell subsets in the in vivo immune response to Theiler's virus in resistant C57BL/10SNJ mice. Depletion of T-cell subsets with monoclonal antibodies (mAbs) directed at CD3 (pan-T-cell marker), CD4(+) (class II-restricted) or CD8(+) (class I-restricted) T cells resulted in increased frequency of paralysis and death as a result of acute encephalitis. Neuropathologic studies 10 days after infection demonstrated prominent necrosis, primarily in the pyramidal layer of hippocampus and in the thalamus of mice depleted of T-cell subsets. In immunosuppressed and infected C57BL/10SNJ mice, analysis of spinal cord sections 35 days after infection demonstrated small demyelinated lesions relatively devoid of inflammatory cells even though virus antigen could be detected by immunocytochemistry. Both CD4(+) and CD8(+) T cells are important in the resistance to infection with Theiler's virus in C57BL/10SNJ mice. However, subsequent spinal cord demyelination, to the extent observed in susceptible mice, depends on the presence of virus antigen persistence and a competent cellular immune response. Published by Elsevier Ltd. 1991-10 2004-04-13 /pmc/articles/PMC7127457/ /pubmed/1687607 http://dx.doi.org/10.1016/0882-4010(91)90031-5 Text en Copyright © 1991 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Rodriguez, Moses
Lindsley, Mark D.
Pierce, Mabel L.
Role of T cells in resistance to Theiler's virus infection()
title Role of T cells in resistance to Theiler's virus infection()
title_full Role of T cells in resistance to Theiler's virus infection()
title_fullStr Role of T cells in resistance to Theiler's virus infection()
title_full_unstemmed Role of T cells in resistance to Theiler's virus infection()
title_short Role of T cells in resistance to Theiler's virus infection()
title_sort role of t cells in resistance to theiler's virus infection()
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127457/
https://www.ncbi.nlm.nih.gov/pubmed/1687607
http://dx.doi.org/10.1016/0882-4010(91)90031-5
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