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Purine analogs as phosphatidylinositol 4-kinase IIIβ inhibitors
We report on an extensive structure–activity relationship study of novel PI4K IIIβ inhibitors. The purine derivative of the potent screening hit T-00127-HEV1 has served as a suitable starting point for a thorough investigation of positions 8 and 2. While position 8 of the purine scaffold can only be...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Ltd.
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127540/ https://www.ncbi.nlm.nih.gov/pubmed/27090557 http://dx.doi.org/10.1016/j.bmcl.2016.04.002 |