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Unique SARS-CoV protein nsp1: bioinformatics, biochemistry and potential effects on virulence
Viruses have evolved a myriad of strategies for promoting viral replication, survival and spread. Sequence analysis of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) genome predicts several proteins that are unique to SARS-CoV. The search to understand the high virulence of SARS-CoV co...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Ltd.
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127589/ https://www.ncbi.nlm.nih.gov/pubmed/17207625 http://dx.doi.org/10.1016/j.tim.2006.12.005 |
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author | Connor, Ramsey F. Roper, Rachel L. |
author_facet | Connor, Ramsey F. Roper, Rachel L. |
author_sort | Connor, Ramsey F. |
collection | PubMed |
description | Viruses have evolved a myriad of strategies for promoting viral replication, survival and spread. Sequence analysis of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) genome predicts several proteins that are unique to SARS-CoV. The search to understand the high virulence of SARS-CoV compared with related coronaviruses, which cause lesser respiratory illnesses, has recently focused on the unique nsp1 protein of SARS-CoV and suggests evolution of a possible new virulence mechanism in coronaviruses. The SARS-CoV nsp1 protein increases cellular RNA degradation and thus might facilitate SARS-CoV replication or block immune responses. |
format | Online Article Text |
id | pubmed-7127589 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71275892020-04-08 Unique SARS-CoV protein nsp1: bioinformatics, biochemistry and potential effects on virulence Connor, Ramsey F. Roper, Rachel L. Trends Microbiol Article Viruses have evolved a myriad of strategies for promoting viral replication, survival and spread. Sequence analysis of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) genome predicts several proteins that are unique to SARS-CoV. The search to understand the high virulence of SARS-CoV compared with related coronaviruses, which cause lesser respiratory illnesses, has recently focused on the unique nsp1 protein of SARS-CoV and suggests evolution of a possible new virulence mechanism in coronaviruses. The SARS-CoV nsp1 protein increases cellular RNA degradation and thus might facilitate SARS-CoV replication or block immune responses. Elsevier Ltd. 2007-02 2007-01-04 /pmc/articles/PMC7127589/ /pubmed/17207625 http://dx.doi.org/10.1016/j.tim.2006.12.005 Text en Copyright © 2006 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Connor, Ramsey F. Roper, Rachel L. Unique SARS-CoV protein nsp1: bioinformatics, biochemistry and potential effects on virulence |
title | Unique SARS-CoV protein nsp1: bioinformatics, biochemistry and potential effects on virulence |
title_full | Unique SARS-CoV protein nsp1: bioinformatics, biochemistry and potential effects on virulence |
title_fullStr | Unique SARS-CoV protein nsp1: bioinformatics, biochemistry and potential effects on virulence |
title_full_unstemmed | Unique SARS-CoV protein nsp1: bioinformatics, biochemistry and potential effects on virulence |
title_short | Unique SARS-CoV protein nsp1: bioinformatics, biochemistry and potential effects on virulence |
title_sort | unique sars-cov protein nsp1: bioinformatics, biochemistry and potential effects on virulence |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127589/ https://www.ncbi.nlm.nih.gov/pubmed/17207625 http://dx.doi.org/10.1016/j.tim.2006.12.005 |
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