Benzylidene/2-chlorobenzylidene hydrazides: Synthesis, antimicrobial activity, QSAR studies and antiviral evaluation

A series of benzylidene hydrazides (1–20) was synthesized and tested, in vitro, for antibacterial, antifungal and antiviral activities. The microbial screening results indicated that compounds having chloro and nitro substituents were the most active ones. The antiviral evaluation depicted that comp...

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Detalles Bibliográficos
Autores principales: Kumar, Davinder, Judge, Vikramjeet, Narang, Rakesh, Sangwan, Sonia, De Clercq, Erik, Balzarini, Jan, Narasimhan, Balasubramanian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127590/
https://www.ncbi.nlm.nih.gov/pubmed/20347509
http://dx.doi.org/10.1016/j.ejmech.2010.03.002
Descripción
Sumario:A series of benzylidene hydrazides (1–20) was synthesized and tested, in vitro, for antibacterial, antifungal and antiviral activities. The microbial screening results indicated that compounds having chloro and nitro substituents were the most active ones. The antiviral evaluation depicted that compounds 9 and 19 were active against Vesicular stomatitis virus (VSV) in HeLa cell cultures. QSAR investigations indicated that the multi-target QSAR model was effective in describing the antimicrobial (antibacterial and antifungal) activity over the one-target QSAR models. Further the mt-QSAR model indicated that the topological parameters, second order molecular connectivity index ((2)χ) and third order Kier's alpha shape index (κα(3)) are effective in describing the antimicrobial activity of synthesized hydrazides.

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