Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives

Aryl diketoacids have been identified as the first SARS-CoV NTPase/helicase inhibitors with a distinct pharmacophore featuring an arylmethyl group attached to a diketoacid. In order to search for the pharmacophore space around the diketoacid core, three classes of dihydroxychromone derivatives were...

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Autores principales: Lee, Chaewoon, Lee, Jin Moo, Lee, Na-Ra, Kim, Dong-Eun, Jeong, Yong-Joo, Chong, Youhoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127646/
https://www.ncbi.nlm.nih.gov/pubmed/19625187
http://dx.doi.org/10.1016/j.bmcl.2009.07.009
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author Lee, Chaewoon
Lee, Jin Moo
Lee, Na-Ra
Kim, Dong-Eun
Jeong, Yong-Joo
Chong, Youhoon
author_facet Lee, Chaewoon
Lee, Jin Moo
Lee, Na-Ra
Kim, Dong-Eun
Jeong, Yong-Joo
Chong, Youhoon
author_sort Lee, Chaewoon
collection PubMed
description Aryl diketoacids have been identified as the first SARS-CoV NTPase/helicase inhibitors with a distinct pharmacophore featuring an arylmethyl group attached to a diketoacid. In order to search for the pharmacophore space around the diketoacid core, three classes of dihydroxychromone derivatives were prepared. Based on SAR study, an extended feature of the pharmacophore model of SARS-CoV NTPase/helicase was proposed which is constituted of a diketoacid core, a hydrophobic arylmethyl substituent, and a free catechol unit.
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spelling pubmed-71276462020-04-08 Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives Lee, Chaewoon Lee, Jin Moo Lee, Na-Ra Kim, Dong-Eun Jeong, Yong-Joo Chong, Youhoon Bioorg Med Chem Lett Article Aryl diketoacids have been identified as the first SARS-CoV NTPase/helicase inhibitors with a distinct pharmacophore featuring an arylmethyl group attached to a diketoacid. In order to search for the pharmacophore space around the diketoacid core, three classes of dihydroxychromone derivatives were prepared. Based on SAR study, an extended feature of the pharmacophore model of SARS-CoV NTPase/helicase was proposed which is constituted of a diketoacid core, a hydrophobic arylmethyl substituent, and a free catechol unit. Elsevier Ltd. 2009-08-15 2009-07-09 /pmc/articles/PMC7127646/ /pubmed/19625187 http://dx.doi.org/10.1016/j.bmcl.2009.07.009 Text en Copyright © 2009 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Lee, Chaewoon
Lee, Jin Moo
Lee, Na-Ra
Kim, Dong-Eun
Jeong, Yong-Joo
Chong, Youhoon
Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives
title Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives
title_full Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives
title_fullStr Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives
title_full_unstemmed Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives
title_short Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives
title_sort investigation of the pharmacophore space of severe acute respiratory syndrome coronavirus (sars-cov) ntpase/helicase by dihydroxychromone derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127646/
https://www.ncbi.nlm.nih.gov/pubmed/19625187
http://dx.doi.org/10.1016/j.bmcl.2009.07.009
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