Thiol-based angiotensin-converting enzyme 2 inhibitors: P(1′) modifications for the exploration of the S(1′) subsite

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Explorations of the S(1′) subsite of ACE2 via modifications of the P(1′) methylene biphenyl moiety of thiol-based metalloprotease inhibitors led to improvements in ACE2 selectivity versus ACE and NEP, while maintaining potent ACE2 inhibition.

Detalles Bibliográficos
Autores principales: Deaton, David N., Graham, Kevin P., Gross, Jeffrey W., Miller, Aaron B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. Published by Elsevier Ltd. 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127737/
https://www.ncbi.nlm.nih.gov/pubmed/18243695
http://dx.doi.org/10.1016/j.bmcl.2008.01.046

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