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The Palm Subdomain-based Active Site is Internally Permuted in Viral RNA-dependent RNA Polymerases of an Ancient Lineage

Template-dependent polynucleotide synthesis is catalyzed by enzymes whose core component includes a ubiquitous αβ palm subdomain comprising A, B and C sequence motifs crucial for catalysis. Due to its unique, universal conservation in all RNA viruses, the palm subdomain of RNA-dependent RNA polymera...

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Detalles Bibliográficos
Autores principales:	Gorbalenya, Alexander E, Pringle, Fiona M, Zeddam, Jean-Louis, Luke, Brian T, Cameron, Craig E, Kalmakoff, James, Hanzlik, Terry N, Gordon, Karl H.J, Ward, Vernon K
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Science Ltd. 2002
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127740/ https://www.ncbi.nlm.nih.gov/pubmed/12421558 http://dx.doi.org/10.1016/S0022-2836(02)01033-1

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