Discovery of novel non-competitive inhibitors of mammalian neutral M1 aminopeptidase (APN)

Neutral metallo-aminopeptidase (APN) catalyzes the cleavage of neutral and basic amino acids from the N-terminus of protein or peptide substrates. APN expression is dysregulated in inflammatory diseases as well as in several types of cancer. Therefore, inhibitors of APN may be effective against canc...

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Detalles Bibliográficos
Autores principales: Pascual, Isel, Valiente, Pedro A., García, Gabriela, Valdés-Tresanco, Mario E., Arrebola, Yarini, Díaz, Lisset, Bounaadja, Lotfi, Uribe, Rosa María, Pacheco, Mae Chappé, Florent, Isabelle, Charli, Jean-Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127808/
https://www.ncbi.nlm.nih.gov/pubmed/28964831
http://dx.doi.org/10.1016/j.biochi.2017.09.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127808/
https://www.ncbi.nlm.nih.gov/pubmed/28964831
http://dx.doi.org/10.1016/j.biochi.2017.09.015

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