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Pre-Clinical Pharmacokinetics, Tissue Distribution and Physicochemical Studies of CLBQ14, a Novel Methionine Aminopeptidase Inhibitor for the Treatment of Infectious Diseases

INTRODUCTION: CLBQ14, a derivative of 8-hydroxyquinoline, exerts its chemotherapeutic effect by inhibiting methionine aminopeptidase (MetAP), the enzyme responsible for the post-translational modification of several proteins and polypeptides. MetAP is a novel target for infectious diseases. CLBQ14 i...

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Detalles Bibliográficos
Autores principales:	Ekpenyong, Oscar, Gao, Xiuqing, Ma, Jing, Cooper, Candace, Nguyen, Linh, Olaleye, Omonike A, Liang, Dong, Xie, Huan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127848/ https://www.ncbi.nlm.nih.gov/pubmed/32280198 http://dx.doi.org/10.2147/DDDT.S238148

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