LncRNA MORT Inhibits Cancer Cell Proliferation and Promotes Apoptosis in Mantle Cell Lymphoma by Upregulating miRNA-16

INTRODUCTION: LncRNA mortal obligate RNA transcript (MORT) is downregulated in different types of cancer, indicating its involvement in cancer biology. METHODS: In this study, MORT and miRNA-16 were both downregulated in plasma of mantle cell lymphoma (MCL) patients than that in the controls. The lo...

Descripción completa

Detalles Bibliográficos
Autores principales: Tang, Xiaoqiong, Long, Yaoying, Xu, Liuyue, Yan, Xinyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127878/
https://www.ncbi.nlm.nih.gov/pubmed/32280273
http://dx.doi.org/10.2147/CMAR.S233859
_version_ 1783516456438202368
author Tang, Xiaoqiong
Long, Yaoying
Xu, Liuyue
Yan, Xinyu
author_facet Tang, Xiaoqiong
Long, Yaoying
Xu, Liuyue
Yan, Xinyu
author_sort Tang, Xiaoqiong
collection PubMed
description INTRODUCTION: LncRNA mortal obligate RNA transcript (MORT) is downregulated in different types of cancer, indicating its involvement in cancer biology. METHODS: In this study, MORT and miRNA-16 were both downregulated in plasma of mantle cell lymphoma (MCL) patients than that in the controls. The low levels of MORT and miRNA-16 were correlated with poor survival of MCL patients. The expression of MORT and miRNA-16 was positively correlated only in MCL patients. RESULTS: Overexpression of MORT and miRNA-16 suppressed cell proliferation but promoted cancer cell apoptosis, while miRNA-16 inhibitor reduced the effects of MORT overexpression. Overexpression of MORT led to upregulated expression of miRNA-16, while overexpression of miRNA-16 had no effect on the expression of MORT. CONCLUSION: Therefore, MORT may inhibit cancer cell proliferation and promote apoptosis in mantle cell lymphoma by upregulating miRNA-16.
format Online
Article
Text
id pubmed-7127878
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-71278782020-04-10 LncRNA MORT Inhibits Cancer Cell Proliferation and Promotes Apoptosis in Mantle Cell Lymphoma by Upregulating miRNA-16 Tang, Xiaoqiong Long, Yaoying Xu, Liuyue Yan, Xinyu Cancer Manag Res Original Research INTRODUCTION: LncRNA mortal obligate RNA transcript (MORT) is downregulated in different types of cancer, indicating its involvement in cancer biology. METHODS: In this study, MORT and miRNA-16 were both downregulated in plasma of mantle cell lymphoma (MCL) patients than that in the controls. The low levels of MORT and miRNA-16 were correlated with poor survival of MCL patients. The expression of MORT and miRNA-16 was positively correlated only in MCL patients. RESULTS: Overexpression of MORT and miRNA-16 suppressed cell proliferation but promoted cancer cell apoptosis, while miRNA-16 inhibitor reduced the effects of MORT overexpression. Overexpression of MORT led to upregulated expression of miRNA-16, while overexpression of miRNA-16 had no effect on the expression of MORT. CONCLUSION: Therefore, MORT may inhibit cancer cell proliferation and promote apoptosis in mantle cell lymphoma by upregulating miRNA-16. Dove 2020-03-23 /pmc/articles/PMC7127878/ /pubmed/32280273 http://dx.doi.org/10.2147/CMAR.S233859 Text en © 2020 Tang et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Tang, Xiaoqiong
Long, Yaoying
Xu, Liuyue
Yan, Xinyu
LncRNA MORT Inhibits Cancer Cell Proliferation and Promotes Apoptosis in Mantle Cell Lymphoma by Upregulating miRNA-16
title LncRNA MORT Inhibits Cancer Cell Proliferation and Promotes Apoptosis in Mantle Cell Lymphoma by Upregulating miRNA-16
title_full LncRNA MORT Inhibits Cancer Cell Proliferation and Promotes Apoptosis in Mantle Cell Lymphoma by Upregulating miRNA-16
title_fullStr LncRNA MORT Inhibits Cancer Cell Proliferation and Promotes Apoptosis in Mantle Cell Lymphoma by Upregulating miRNA-16
title_full_unstemmed LncRNA MORT Inhibits Cancer Cell Proliferation and Promotes Apoptosis in Mantle Cell Lymphoma by Upregulating miRNA-16
title_short LncRNA MORT Inhibits Cancer Cell Proliferation and Promotes Apoptosis in Mantle Cell Lymphoma by Upregulating miRNA-16
title_sort lncrna mort inhibits cancer cell proliferation and promotes apoptosis in mantle cell lymphoma by upregulating mirna-16
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127878/
https://www.ncbi.nlm.nih.gov/pubmed/32280273
http://dx.doi.org/10.2147/CMAR.S233859
work_keys_str_mv AT tangxiaoqiong lncrnamortinhibitscancercellproliferationandpromotesapoptosisinmantlecelllymphomabyupregulatingmirna16
AT longyaoying lncrnamortinhibitscancercellproliferationandpromotesapoptosisinmantlecelllymphomabyupregulatingmirna16
AT xuliuyue lncrnamortinhibitscancercellproliferationandpromotesapoptosisinmantlecelllymphomabyupregulatingmirna16
AT yanxinyu lncrnamortinhibitscancercellproliferationandpromotesapoptosisinmantlecelllymphomabyupregulatingmirna16

Ejemplares similares