Synthesis of Potent Cytotoxic Epidithiodiketopiperazines Designed for Derivatization

[Image: see text] We describe our design, synthesis, and chemical study of a set of functional epidithiodiketopiperazines (ETPs) and evaluation of their activity against five human cancer cell lines. Our structure–activity relationship-guided substitution of ETP alkaloids offers versatile derivatiza...

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Detalles Bibliográficos
Autores principales: Olsson, Chase R., Payette, Joshua N., Cheah, Jaime H., Movassaghi, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127967/
https://www.ncbi.nlm.nih.gov/pubmed/32126173
http://dx.doi.org/10.1021/acs.joc.9b03371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127967/
https://www.ncbi.nlm.nih.gov/pubmed/32126173
http://dx.doi.org/10.1021/acs.joc.9b03371

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