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Association between Serum Ferritin and Blood Lipids: Influence of Diabetes and hs-CRP Levels
This study is aimed at exploring the relationship between serum ferritin and blood lipids and the influence of diabetes and different hs-CRP levels. A total of 8163 subjects were analyzed. Participators were classified according to serum ferritin, diabetes, and two hs-CRP levels. Blood lipids were d...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128071/ https://www.ncbi.nlm.nih.gov/pubmed/32280714 http://dx.doi.org/10.1155/2020/4138696 |
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author | Yu, Lianlong Yan, Jingyi Zhang, Qian Lin, Hong Zhu, Lichao Liu, Qiangqiang Zhao, Changsheng |
author_facet | Yu, Lianlong Yan, Jingyi Zhang, Qian Lin, Hong Zhu, Lichao Liu, Qiangqiang Zhao, Changsheng |
author_sort | Yu, Lianlong |
collection | PubMed |
description | This study is aimed at exploring the relationship between serum ferritin and blood lipids and the influence of diabetes and different hs-CRP levels. A total of 8163 subjects were analyzed. Participators were classified according to serum ferritin, diabetes, and two hs-CRP levels. Blood lipids were determined using standardized methods and conditions. Except for HDL-C, there was a significant increase in blood lipids in the progressive ferritin group with normal hs-CRP levels (P < 0.05). But HDL-C was just the opposite (P < 0.0001). In nondiabetic patients, TG, TC, and LDL-C were significantly elevated in the progressive ferritin group (P < 0.05). And, HDL-C was just the opposite (P < 0.05). The generalized linear model and the parsimonious model showed that serum TG was positively correlated with ferritin, and LDL-C was negatively correlated with ferritin (P < 0.05). But the correlation between LDL-C and ferritin was broken (P > 0.05). After a sufficient adjustment, there was a positive correlation between serum TG and ferritin and a negative correlation between LDL-C and ferritin. Nonetheless, a negative correlation between LDL-C and ferritin is influenced by diabetes frailly. And, there was no change of relationship between lipids and ferritin in different hs-CRP levels. We found a real relationship between ferritin and lipids after sufficient adjustment for confounders. |
format | Online Article Text |
id | pubmed-7128071 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-71280712020-04-10 Association between Serum Ferritin and Blood Lipids: Influence of Diabetes and hs-CRP Levels Yu, Lianlong Yan, Jingyi Zhang, Qian Lin, Hong Zhu, Lichao Liu, Qiangqiang Zhao, Changsheng J Diabetes Res Research Article This study is aimed at exploring the relationship between serum ferritin and blood lipids and the influence of diabetes and different hs-CRP levels. A total of 8163 subjects were analyzed. Participators were classified according to serum ferritin, diabetes, and two hs-CRP levels. Blood lipids were determined using standardized methods and conditions. Except for HDL-C, there was a significant increase in blood lipids in the progressive ferritin group with normal hs-CRP levels (P < 0.05). But HDL-C was just the opposite (P < 0.0001). In nondiabetic patients, TG, TC, and LDL-C were significantly elevated in the progressive ferritin group (P < 0.05). And, HDL-C was just the opposite (P < 0.05). The generalized linear model and the parsimonious model showed that serum TG was positively correlated with ferritin, and LDL-C was negatively correlated with ferritin (P < 0.05). But the correlation between LDL-C and ferritin was broken (P > 0.05). After a sufficient adjustment, there was a positive correlation between serum TG and ferritin and a negative correlation between LDL-C and ferritin. Nonetheless, a negative correlation between LDL-C and ferritin is influenced by diabetes frailly. And, there was no change of relationship between lipids and ferritin in different hs-CRP levels. We found a real relationship between ferritin and lipids after sufficient adjustment for confounders. Hindawi 2020-03-24 /pmc/articles/PMC7128071/ /pubmed/32280714 http://dx.doi.org/10.1155/2020/4138696 Text en Copyright © 2020 Lianlong Yu et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Yu, Lianlong Yan, Jingyi Zhang, Qian Lin, Hong Zhu, Lichao Liu, Qiangqiang Zhao, Changsheng Association between Serum Ferritin and Blood Lipids: Influence of Diabetes and hs-CRP Levels |
title | Association between Serum Ferritin and Blood Lipids: Influence of Diabetes and hs-CRP Levels |
title_full | Association between Serum Ferritin and Blood Lipids: Influence of Diabetes and hs-CRP Levels |
title_fullStr | Association between Serum Ferritin and Blood Lipids: Influence of Diabetes and hs-CRP Levels |
title_full_unstemmed | Association between Serum Ferritin and Blood Lipids: Influence of Diabetes and hs-CRP Levels |
title_short | Association between Serum Ferritin and Blood Lipids: Influence of Diabetes and hs-CRP Levels |
title_sort | association between serum ferritin and blood lipids: influence of diabetes and hs-crp levels |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128071/ https://www.ncbi.nlm.nih.gov/pubmed/32280714 http://dx.doi.org/10.1155/2020/4138696 |
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