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CD8 memory T cells: cross-reactivity and heterologous immunity
Virus-specific memory T cell populations demonstrate plasticity in antigen recognition and in their ability to accommodate new memory T cell populations. The degeneracy of T cell antigen recognition and the flexibility of diverse antigen-specific repertoires allow the host to respond to a multitude...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Ltd.
2004
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128110/ https://www.ncbi.nlm.nih.gov/pubmed/15528078 http://dx.doi.org/10.1016/j.smim.2004.08.014 |
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author | Selin, Liisa K. Cornberg, Markus Brehm, Michael A. Kim, Sung-Kwon Calcagno, Claudia Ghersi, Dario Puzone, Roberto Celada, Franco Welsh, Raymond M. |
author_facet | Selin, Liisa K. Cornberg, Markus Brehm, Michael A. Kim, Sung-Kwon Calcagno, Claudia Ghersi, Dario Puzone, Roberto Celada, Franco Welsh, Raymond M. |
author_sort | Selin, Liisa K. |
collection | PubMed |
description | Virus-specific memory T cell populations demonstrate plasticity in antigen recognition and in their ability to accommodate new memory T cell populations. The degeneracy of T cell antigen recognition and the flexibility of diverse antigen-specific repertoires allow the host to respond to a multitude of pathogens while accommodating these numerous large memory pools in a finite immune system. These cross-reactive memory T cells can be employed in immune responses and mediate protective immunity, but they can also induce life-threatening immunopathology or impede transplantation tolerance and graft survival. Here we discuss examples of altered viral pathogenesis occurring as a consequence of heterologous T cell immunity and propose models for the maintenance of a dynamic pool of memory cells. |
format | Online Article Text |
id | pubmed-7128110 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2004 |
publisher | Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71281102020-04-08 CD8 memory T cells: cross-reactivity and heterologous immunity Selin, Liisa K. Cornberg, Markus Brehm, Michael A. Kim, Sung-Kwon Calcagno, Claudia Ghersi, Dario Puzone, Roberto Celada, Franco Welsh, Raymond M. Semin Immunol Article Virus-specific memory T cell populations demonstrate plasticity in antigen recognition and in their ability to accommodate new memory T cell populations. The degeneracy of T cell antigen recognition and the flexibility of diverse antigen-specific repertoires allow the host to respond to a multitude of pathogens while accommodating these numerous large memory pools in a finite immune system. These cross-reactive memory T cells can be employed in immune responses and mediate protective immunity, but they can also induce life-threatening immunopathology or impede transplantation tolerance and graft survival. Here we discuss examples of altered viral pathogenesis occurring as a consequence of heterologous T cell immunity and propose models for the maintenance of a dynamic pool of memory cells. Elsevier Ltd. 2004-10 2004-10-26 /pmc/articles/PMC7128110/ /pubmed/15528078 http://dx.doi.org/10.1016/j.smim.2004.08.014 Text en Copyright © 2004 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Selin, Liisa K. Cornberg, Markus Brehm, Michael A. Kim, Sung-Kwon Calcagno, Claudia Ghersi, Dario Puzone, Roberto Celada, Franco Welsh, Raymond M. CD8 memory T cells: cross-reactivity and heterologous immunity |
title | CD8 memory T cells: cross-reactivity and heterologous immunity |
title_full | CD8 memory T cells: cross-reactivity and heterologous immunity |
title_fullStr | CD8 memory T cells: cross-reactivity and heterologous immunity |
title_full_unstemmed | CD8 memory T cells: cross-reactivity and heterologous immunity |
title_short | CD8 memory T cells: cross-reactivity and heterologous immunity |
title_sort | cd8 memory t cells: cross-reactivity and heterologous immunity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128110/ https://www.ncbi.nlm.nih.gov/pubmed/15528078 http://dx.doi.org/10.1016/j.smim.2004.08.014 |
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