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CD8 memory T cells: cross-reactivity and heterologous immunity

Virus-specific memory T cell populations demonstrate plasticity in antigen recognition and in their ability to accommodate new memory T cell populations. The degeneracy of T cell antigen recognition and the flexibility of diverse antigen-specific repertoires allow the host to respond to a multitude...

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Detalles Bibliográficos
Autores principales: Selin, Liisa K., Cornberg, Markus, Brehm, Michael A., Kim, Sung-Kwon, Calcagno, Claudia, Ghersi, Dario, Puzone, Roberto, Celada, Franco, Welsh, Raymond M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128110/
https://www.ncbi.nlm.nih.gov/pubmed/15528078
http://dx.doi.org/10.1016/j.smim.2004.08.014
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author Selin, Liisa K.
Cornberg, Markus
Brehm, Michael A.
Kim, Sung-Kwon
Calcagno, Claudia
Ghersi, Dario
Puzone, Roberto
Celada, Franco
Welsh, Raymond M.
author_facet Selin, Liisa K.
Cornberg, Markus
Brehm, Michael A.
Kim, Sung-Kwon
Calcagno, Claudia
Ghersi, Dario
Puzone, Roberto
Celada, Franco
Welsh, Raymond M.
author_sort Selin, Liisa K.
collection PubMed
description Virus-specific memory T cell populations demonstrate plasticity in antigen recognition and in their ability to accommodate new memory T cell populations. The degeneracy of T cell antigen recognition and the flexibility of diverse antigen-specific repertoires allow the host to respond to a multitude of pathogens while accommodating these numerous large memory pools in a finite immune system. These cross-reactive memory T cells can be employed in immune responses and mediate protective immunity, but they can also induce life-threatening immunopathology or impede transplantation tolerance and graft survival. Here we discuss examples of altered viral pathogenesis occurring as a consequence of heterologous T cell immunity and propose models for the maintenance of a dynamic pool of memory cells.
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spelling pubmed-71281102020-04-08 CD8 memory T cells: cross-reactivity and heterologous immunity Selin, Liisa K. Cornberg, Markus Brehm, Michael A. Kim, Sung-Kwon Calcagno, Claudia Ghersi, Dario Puzone, Roberto Celada, Franco Welsh, Raymond M. Semin Immunol Article Virus-specific memory T cell populations demonstrate plasticity in antigen recognition and in their ability to accommodate new memory T cell populations. The degeneracy of T cell antigen recognition and the flexibility of diverse antigen-specific repertoires allow the host to respond to a multitude of pathogens while accommodating these numerous large memory pools in a finite immune system. These cross-reactive memory T cells can be employed in immune responses and mediate protective immunity, but they can also induce life-threatening immunopathology or impede transplantation tolerance and graft survival. Here we discuss examples of altered viral pathogenesis occurring as a consequence of heterologous T cell immunity and propose models for the maintenance of a dynamic pool of memory cells. Elsevier Ltd. 2004-10 2004-10-26 /pmc/articles/PMC7128110/ /pubmed/15528078 http://dx.doi.org/10.1016/j.smim.2004.08.014 Text en Copyright © 2004 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Selin, Liisa K.
Cornberg, Markus
Brehm, Michael A.
Kim, Sung-Kwon
Calcagno, Claudia
Ghersi, Dario
Puzone, Roberto
Celada, Franco
Welsh, Raymond M.
CD8 memory T cells: cross-reactivity and heterologous immunity
title CD8 memory T cells: cross-reactivity and heterologous immunity
title_full CD8 memory T cells: cross-reactivity and heterologous immunity
title_fullStr CD8 memory T cells: cross-reactivity and heterologous immunity
title_full_unstemmed CD8 memory T cells: cross-reactivity and heterologous immunity
title_short CD8 memory T cells: cross-reactivity and heterologous immunity
title_sort cd8 memory t cells: cross-reactivity and heterologous immunity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128110/
https://www.ncbi.nlm.nih.gov/pubmed/15528078
http://dx.doi.org/10.1016/j.smim.2004.08.014
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