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Immunopathogenesis of porcine reproductive and respiratory syndrome in the respiratory tract of pigs

Porcine reproductive and respiratory syndrome (PRRS) virus (PRRSV) impairs local pulmonary immune responses by damaging the mucociliary transport system, impairing the function of porcine alveolar macrophages and inducing apoptosis of immune cells. An imbalance between pro- and anti-inflammatory cyt...

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Autores principales: Gómez-Laguna, Jaime, Salguero, Francisco J., Pallarés, Francisco J., Carrasco, Librado
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128372/
https://www.ncbi.nlm.nih.gov/pubmed/23265866
http://dx.doi.org/10.1016/j.tvjl.2012.11.012
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author Gómez-Laguna, Jaime
Salguero, Francisco J.
Pallarés, Francisco J.
Carrasco, Librado
author_facet Gómez-Laguna, Jaime
Salguero, Francisco J.
Pallarés, Francisco J.
Carrasco, Librado
author_sort Gómez-Laguna, Jaime
collection PubMed
description Porcine reproductive and respiratory syndrome (PRRS) virus (PRRSV) impairs local pulmonary immune responses by damaging the mucociliary transport system, impairing the function of porcine alveolar macrophages and inducing apoptosis of immune cells. An imbalance between pro- and anti-inflammatory cytokines, including tumour necrosis factor-α and interleukin-10, in PRRS may impair the immune response of the lung. Pulmonary macrophage subpopulations have a range of susceptibilities to different PRRSV strains and different capacities to express cytokines. Infection with PRRSV decreases the bactericidal activity of macrophages, which increases susceptibility to secondary bacterial infections. PRRSV infection is associated with an increase in concentrations of haptoglobin, which may interact with the virus receptor (CD163) and induce the synthesis of anti-inflammatory mediators. The balance between pro- and anti-inflammatory cytokines modulates the expression of CD163, which may affect the pathogenicity and replication of the virus in different tissues. With the emergence of highly pathogenic PRRSV, there is a need for more information on the immunopathogenesis of different strains of PRRS, particularly to develop more effective vaccines.
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spelling pubmed-71283722020-04-06 Immunopathogenesis of porcine reproductive and respiratory syndrome in the respiratory tract of pigs Gómez-Laguna, Jaime Salguero, Francisco J. Pallarés, Francisco J. Carrasco, Librado Vet J Article Porcine reproductive and respiratory syndrome (PRRS) virus (PRRSV) impairs local pulmonary immune responses by damaging the mucociliary transport system, impairing the function of porcine alveolar macrophages and inducing apoptosis of immune cells. An imbalance between pro- and anti-inflammatory cytokines, including tumour necrosis factor-α and interleukin-10, in PRRS may impair the immune response of the lung. Pulmonary macrophage subpopulations have a range of susceptibilities to different PRRSV strains and different capacities to express cytokines. Infection with PRRSV decreases the bactericidal activity of macrophages, which increases susceptibility to secondary bacterial infections. PRRSV infection is associated with an increase in concentrations of haptoglobin, which may interact with the virus receptor (CD163) and induce the synthesis of anti-inflammatory mediators. The balance between pro- and anti-inflammatory cytokines modulates the expression of CD163, which may affect the pathogenicity and replication of the virus in different tissues. With the emergence of highly pathogenic PRRSV, there is a need for more information on the immunopathogenesis of different strains of PRRS, particularly to develop more effective vaccines. Elsevier Ltd. 2013-02 2012-12-20 /pmc/articles/PMC7128372/ /pubmed/23265866 http://dx.doi.org/10.1016/j.tvjl.2012.11.012 Text en Copyright © 2012 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Gómez-Laguna, Jaime
Salguero, Francisco J.
Pallarés, Francisco J.
Carrasco, Librado
Immunopathogenesis of porcine reproductive and respiratory syndrome in the respiratory tract of pigs
title Immunopathogenesis of porcine reproductive and respiratory syndrome in the respiratory tract of pigs
title_full Immunopathogenesis of porcine reproductive and respiratory syndrome in the respiratory tract of pigs
title_fullStr Immunopathogenesis of porcine reproductive and respiratory syndrome in the respiratory tract of pigs
title_full_unstemmed Immunopathogenesis of porcine reproductive and respiratory syndrome in the respiratory tract of pigs
title_short Immunopathogenesis of porcine reproductive and respiratory syndrome in the respiratory tract of pigs
title_sort immunopathogenesis of porcine reproductive and respiratory syndrome in the respiratory tract of pigs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128372/
https://www.ncbi.nlm.nih.gov/pubmed/23265866
http://dx.doi.org/10.1016/j.tvjl.2012.11.012
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