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COVID-19: A promising cure for the global panic

The novel Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, which is the causative agent of a potentially fatal disease that is of great global public health concern. The outbreak of COVID-19 is wreaking havoc worldwide due to inadequate risk assessment regarding the urgency of the situat...

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Autores principales: Vellingiri, Balachandar, Jayaramayya, Kaavya, Iyer, Mahalaxmi, Narayanasamy, Arul, Govindasamy, Vivekanandhan, Giridharan, Bupesh, Ganesan, Singaravelu, Venugopal, Anila, Venkatesan, Dhivya, Ganesan, Harsha, Rajagopalan, Kamarajan, Rahman, Pattanathu K.S.M., Cho, Ssang-Goo, Kumar, Nachimuthu Senthil, Subramaniam, Mohana Devi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128376/
https://www.ncbi.nlm.nih.gov/pubmed/32278175
http://dx.doi.org/10.1016/j.scitotenv.2020.138277
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author Vellingiri, Balachandar
Jayaramayya, Kaavya
Iyer, Mahalaxmi
Narayanasamy, Arul
Govindasamy, Vivekanandhan
Giridharan, Bupesh
Ganesan, Singaravelu
Venugopal, Anila
Venkatesan, Dhivya
Ganesan, Harsha
Rajagopalan, Kamarajan
Rahman, Pattanathu K.S.M.
Cho, Ssang-Goo
Kumar, Nachimuthu Senthil
Subramaniam, Mohana Devi
author_facet Vellingiri, Balachandar
Jayaramayya, Kaavya
Iyer, Mahalaxmi
Narayanasamy, Arul
Govindasamy, Vivekanandhan
Giridharan, Bupesh
Ganesan, Singaravelu
Venugopal, Anila
Venkatesan, Dhivya
Ganesan, Harsha
Rajagopalan, Kamarajan
Rahman, Pattanathu K.S.M.
Cho, Ssang-Goo
Kumar, Nachimuthu Senthil
Subramaniam, Mohana Devi
author_sort Vellingiri, Balachandar
collection PubMed
description The novel Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, which is the causative agent of a potentially fatal disease that is of great global public health concern. The outbreak of COVID-19 is wreaking havoc worldwide due to inadequate risk assessment regarding the urgency of the situation. The COVID-19 pandemic has entered a dangerous new phase. When compared with SARS and MERS, COVID-19 has spread more rapidly, due to increased globalization and adaptation of the virus in every environment. Slowing the spread of the COVID-19 cases will significantly reduce the strain on the healthcare system of the country by limiting the number of people who are severely sick by COVID-19 and need hospital care. Hence, the recent outburst of COVID-19 highlights an urgent need for therapeutics targeting SARS-CoV-2. Here, we have discussed the structure of virus; varying symptoms among COVID-19, SARS, MERS and common flu; the probable mechanism behind the infection and its immune response. Further, the current treatment options, drugs available, ongoing trials and recent diagnostics for COVID-19 have been discussed. We suggest traditional Indian medicinal plants as possible novel therapeutic approaches, exclusively targeting SARS-CoV-2 and its pathways.
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spelling pubmed-71283762020-04-08 COVID-19: A promising cure for the global panic Vellingiri, Balachandar Jayaramayya, Kaavya Iyer, Mahalaxmi Narayanasamy, Arul Govindasamy, Vivekanandhan Giridharan, Bupesh Ganesan, Singaravelu Venugopal, Anila Venkatesan, Dhivya Ganesan, Harsha Rajagopalan, Kamarajan Rahman, Pattanathu K.S.M. Cho, Ssang-Goo Kumar, Nachimuthu Senthil Subramaniam, Mohana Devi Sci Total Environ Review The novel Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, which is the causative agent of a potentially fatal disease that is of great global public health concern. The outbreak of COVID-19 is wreaking havoc worldwide due to inadequate risk assessment regarding the urgency of the situation. The COVID-19 pandemic has entered a dangerous new phase. When compared with SARS and MERS, COVID-19 has spread more rapidly, due to increased globalization and adaptation of the virus in every environment. Slowing the spread of the COVID-19 cases will significantly reduce the strain on the healthcare system of the country by limiting the number of people who are severely sick by COVID-19 and need hospital care. Hence, the recent outburst of COVID-19 highlights an urgent need for therapeutics targeting SARS-CoV-2. Here, we have discussed the structure of virus; varying symptoms among COVID-19, SARS, MERS and common flu; the probable mechanism behind the infection and its immune response. Further, the current treatment options, drugs available, ongoing trials and recent diagnostics for COVID-19 have been discussed. We suggest traditional Indian medicinal plants as possible novel therapeutic approaches, exclusively targeting SARS-CoV-2 and its pathways. Elsevier B.V. 2020-07-10 2020-04-04 /pmc/articles/PMC7128376/ /pubmed/32278175 http://dx.doi.org/10.1016/j.scitotenv.2020.138277 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Vellingiri, Balachandar
Jayaramayya, Kaavya
Iyer, Mahalaxmi
Narayanasamy, Arul
Govindasamy, Vivekanandhan
Giridharan, Bupesh
Ganesan, Singaravelu
Venugopal, Anila
Venkatesan, Dhivya
Ganesan, Harsha
Rajagopalan, Kamarajan
Rahman, Pattanathu K.S.M.
Cho, Ssang-Goo
Kumar, Nachimuthu Senthil
Subramaniam, Mohana Devi
COVID-19: A promising cure for the global panic
title COVID-19: A promising cure for the global panic
title_full COVID-19: A promising cure for the global panic
title_fullStr COVID-19: A promising cure for the global panic
title_full_unstemmed COVID-19: A promising cure for the global panic
title_short COVID-19: A promising cure for the global panic
title_sort covid-19: a promising cure for the global panic
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128376/
https://www.ncbi.nlm.nih.gov/pubmed/32278175
http://dx.doi.org/10.1016/j.scitotenv.2020.138277
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